Deep Learning Image Analysis of Benign Breast Disease to Identify Subsequent Risk of Breast Cancer.

Journal: JNCI cancer spectrum
PMID: 33644680

Abstract

BACKGROUND: New biomarkers of risk may improve breast cancer (BC) risk prediction. We developed a computational pathology method to segment benign breast disease (BBD) whole slide images into epithelium, fibrous stroma, and fat. We applied our method to the BBD BC nested case-control study within the Nurses' Health Studies to assess whether computer-derived tissue composition or a morphometric signature was associated with subsequent risk of BC.

Authors

  • Adithya D Vellal
    Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Korsuk Sirinukunwattan
    Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Kevin H Kensler
    Division of Population Sciences, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America.
  • Gabrielle M Baker
    Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.
  • Andreea L Stancu
    Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Michael E Pyle
    Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.
  • Laura C Collins
    Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.
  • Stuart J Schnitt
    Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Dana-Farber Cancer Institute-Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
  • James L Connolly
    Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Mitko Veta
    Medical Image Analysis Group, Eindhoven University of Technology, Eindhoven, the Netherlands.
  • A Heather Eliassen
    Channing Division of Network Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
  • Rulla M Tamimi
    Associate Professor, Department of Medicine, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
  • Yujing J Heng
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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