Modeling autosomal dominant Alzheimer's disease with machine learning.

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
PMID:

Abstract

INTRODUCTION: Machine learning models were used to discover novel disease trajectories for autosomal dominant Alzheimer's disease.

Authors

  • Patrick H Luckett
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Austin McCullough
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Brian A Gordon
    Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA.
  • Jeremy Strain
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Shaney Flores
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Aylin Dincer
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • John McCarthy
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Todd Kuffner
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Ari Stern
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Karin L Meeker
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Sarah B Berman
    Neurology, University of Pittsburgh School of Medicine Pittsburgh, PA.
  • Jasmeer P Chhatwal
    Brigham and Women's Hospital, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Carlos Cruchaga
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Anne M Fagan
    Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Martin R Farlow
    Indiana University, Bloomington, Indiana, USA.
  • Nick C Fox
    Dementia Research Centre, University College London, Queen Square, London, UK.
  • Mathias Jucker
    German Center for Neurodegenerative Disease, Tübingen, Germany.
  • Johannes Levin
    Munich Cluster for Systems Neurology, Munich, Germany.
  • Colin L Masters
    Florey Institute, The University of Melbourne, Parkville, VIC, 3052, Australia.
  • Hiroshi Mori
    Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan.
  • James M Noble
    Taub Institute for Research on Alzheimer's Disease and the Aging Brain, G.H. Sergievsky Center and Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
  • Stephen Salloway
    Department of Neurology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
  • Peter R Schofield
    Neuroscience Research Australia, Randwick, New South Wales, Australia.
  • Adam M Brickman
    Columbia University, New York, New York, USA.
  • William S Brooks
    Neuroscience Research Australia, Randwick, NSW, Australia.
  • David M Cash
    Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
  • Michael J Fulham
    Department of Molecular Imaging, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW, Australia.
  • Bernardino Ghetti
    Indiana University, Bloomington, Indiana, USA.
  • Clifford R Jack
    Department of Radiology, Mayo Clinic and Foundation, Rochester, MN, USA.
  • Jonathan Vöglein
    German Center for Neurodegenerative Diseases, Munich, Germany.
  • William Klunk
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Robert Koeppe
    University of Michigan, Ann Arbor, Michigan, USA.
  • Hwamee Oh
    Brown University, Providence, Rhode Island, USA.
  • Yi Su
    Department of Gastroenterology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
  • Michael Weiner
    Department of Psychiatry, University of California, San Francisco and San Francisco VA Medical Center, San Francisco, CA, USA.
  • Qing Wang
    School of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China. qwang@163.com.
  • Laura Swisher
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Dan Marcus
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Deborah Koudelis
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Nelly Joseph-Mathurin
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Lisa Cash
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Russ Hornbeck
    Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA.
  • Chengjie Xiong
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Richard J Perrin
    Washington University in St. Louis, St. Louis, Missouri, USA.
  • Celeste M Karch
    Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Jason Hassenstab
    Department of Neurology, Washington University in St. Louis, MO, USA; Psychological & Brain Sciences, Washington University in St. Louis, MO, USA.
  • Eric McDade
    Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.
  • John C Morris
    Knight Alzheimer Disease Research Center, Washington University in St. Louis, St. Louis, MO, USA.
  • Tammie L S Benzinger
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
  • Randall J Bateman
    Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Beau M Ances
    Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Department of Neurology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA.