Derivation and validation of a machine learning risk score using biomarker and electronic patient data to predict progression of diabetic kidney disease.

Journal: Diabetologia
PMID:

Abstract

AIM: Predicting progression in diabetic kidney disease (DKD) is critical to improving outcomes. We sought to develop/validate a machine-learned, prognostic risk score (KidneyIntelXâ„¢) combining electronic health records (EHR) and biomarkers.

Authors

  • Lili Chan
    Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Girish N Nadkarni
    Division of Data-Driven and Digital Medicine (D3M), Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Fergus Fleming
    Renalytix AI Plc, Cardiff, UK.
  • James R McCullough
    Renalytix AI Plc, Cardiff, UK.
  • Patricia Connolly
    Renalytix AI Plc, Cardiff, UK.
  • Gohar Mosoyan
    Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Fadi El Salem
    Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Michael W Kattan
  • Joseph A Vassalotti
    Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Barbara Murphy
    Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • Michael J Donovan
    Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Steven G Coca
    Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Scott M Damrauer
    Department of Surgery, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, USA. damrauer@upenn.edu.