Synthesis and biological characterization of MnZnEuDyFeO nanoparticles by sonochemical approach.
Journal:
Materials science & engineering. C, Materials for biological applications
Published Date:
Dec 6, 2019
Abstract
Metallic nanoparticles (NPs) possess unique properties which makes them attractive candidates for various applications especially in field of experimental medicine and drug delivery. Many approaches were developed to synthesize divers and customized metallic NPs that can be useful in many areas such as, experimental medicine, drug design, drug delivery, electrical and electronic engineering, electrochemical sensors, and biochemical sensors. Among different metallic nanoparticles, manganese (Mn) NPs are the most prominent materials, in the present study, we have synthetized unique MnZnDyEuFeO NPs by using ultrasonication method (x ≤ 0.1). The structure, and surface morphology of MnZnDyEuFeO NPs was characterized by XRD, SEM, TEM and EDX methods. We have examined the biological effects of MnZnDyEuFeO NPs on both normal (HEK-293) and cancerous (HCT-116) cells. We have found that the treatment of MnZnDyEuFeO NPs post 48 h, showed significant decline in cancer cells population as revealed by MTT assay. The IC value of MnZnDyEuFeO NPs was ranged between (2.35 μg/mL to 2.33 μg/mL). To check the specificity of the actions, we found that the treatment of MnZnDyEuFeO NPs did not produce any effects on the normal cells, which suggest that MnZnDyEuFeO NPs selectively targeted the cancerous cells. The anti-bacterial properties of MnZnDyEuFeO NPs were also evaluated by MIC and MBC assays. We suggest that MnZnDyEuFeO NPs produced by sonochemical method possess potential anti-cancer and anti-bacterial capabilities.