Real-time prediction of intradialytic relative blood volume: a proof-of-concept for integrated cloud computing infrastructure.

Journal: BMC nephrology
PMID: 34372809

Abstract

BACKGROUND: Inadequate refilling from extravascular compartments during hemodialysis can lead to intradialytic symptoms, such as hypotension, nausea, vomiting, and cramping/myalgia. Relative blood volume (RBV) plays an important role in adapting the ultrafiltration rate which in turn has a positive effect on intradialytic symptoms. It has been clinically challenging to identify changes RBV in real time to proactively intervene and reduce potential negative consequences of volume depletion. Leveraging advanced technologies to process large volumes of dialysis and machine data in real time and developing prediction models using machine learning (ML) is critical in identifying these signals.

Authors

  • Sheetal Chaudhuri
    Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
  • Hao Han
    Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore.
  • Caitlin Monaghan
    Fresenius Medical Care, Global Medical Office, 920 Winter Street, Waltham, MA, 02451, USA.
  • John Larkin
    Fresenius Medical Care, Global Medical Office, 920 Winter Street, Waltham, MA, 02451, USA.
  • Peter Waguespack
    Fresenius Medical Care North America, Waltham, MA, USA.
  • Brian Shulman
    Fresenius Medical Care North America, Waltham, MA, USA.
  • Zuwen Kuang
    Fresenius Medical Care North America, Waltham, MA, USA.
  • Srikanth Bellamkonda
    Fresenius Medical Care North America, Waltham, MA, USA.
  • Jane Brzozowski
    Fresenius Medical Care, Global Medical Office, 920 Winter Street, Waltham, MA, 02451, USA.
  • Jeffrey Hymes
    Fresenius Medical Care North America, Waltham, MA, USA.
  • Mike Black
    Fresenius Medical Care North America, Waltham, MA, USA.
  • Peter Kotanko
    Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Renal Research Institute, New York, New York, USA.
  • Jeroen P Kooman
    Department of Internal Medicine, Division of Nephrology, University Hospital Maastricht, Maastricht, The Netherlands.
  • Franklin W Maddux
    Fresenius Medical Care, Global Medical Office, 920 Winter Street, Waltham, MA, 02451, USA.
  • Len Usvyat
    Fresenius Medical Care, Global Medical Office, 920 Winter Street, Waltham, MA, 02451, USA.

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