Rongchang and Xifeng capsules suppress pentylenetetrazole-induced seizures and change rest/wake behavior in zebrafish larvae.

Journal: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
PMID:

Abstract

OBJECTIVE: To evaluate the effects of Rongchang capsule and Xifeng capsule on pentylenetetrazole- induced epilepsy in zebrafish larvae and to explore the possible mechanisms behind their actions.

Authors

  • Shuhui Zhang
    State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education.
  • Jia Xu
    Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (Nanjing Tech), 30 South Puzhu Road, Nanjing, 211816, P.R. China.
  • Chao Wang
    College of Agriculture, Shanxi Agricultural University, Taigu, Shanxi, China.
  • Daofu Feng
    Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.
  • Liangti Dai
    State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education.
  • Xiangyu Kuang
    State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education.
  • Shuyi Zhu
    State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education.
  • Yongchun Fang
    The Institute of Robotics and Automatic Information Systems, Tianjin Key Laboratory of Intelligent Robotics, Nankai University, Tianjin 300071, China.
  • Dongyan Chen
    Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Department of Histology and Embryology, School of Medicine, Nankai University, Tianjin 300071, China.
  • Xianghui He
    Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China.
  • Xizeng Feng
    State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education.