AIMC Topic: Pentylenetetrazole

Clear Filters Showing 1 to 6 of 6 articles

Machine learning enables high-throughput, low-replicate screening for novel anti-seizure targets and compounds using combined movement and calcium fluorescence in larval zebrafish.

European journal of pharmacology Feb 4, 2025
Identifying new anti-seizure medications (ASMs) is difficult due to limitations in animal-based assays. Zebrafish (Danio rerio) serve as a model for chemical and genetic seizures, but current methods for detecting anti-seizure responses are limited b...
Seizures Anticonvulsants Drug Evaluation, Preclinical Larva Pentylenetetrazole High-Throughput Screening Assays Movement Valproic Acid Zebrafish Calcium Animals Fluorescence Machine Learning
View on PubMed DOI

Development and applications of a machine learning model for an in-depth analysis of pentylenetetrazol-induced seizure-like behaviors in adult zebrafish.

Neuroscience Jan 27, 2025
Epilepsy, a neurological disorder causing recurring seizures, is often studied in zebrafish by exposing animals to pentylenetetrazol (PTZ), which induces clonic- and tonic-like behaviors. While adult zebrafish seizure-like behaviors are well characte...
Disease Models, Animal Pentylenetetrazole Seizures Machine Learning Animals Convulsants Anticonvulsants Valproic Acid Diazepam Zebrafish Behavior, Animal
View on PubMed DOI

Quercetin Exerts Anticonvulsant Effect through Mitigation of Neuroinflammatory Response in Pentylenetetrazole-induced Seizure in Mice.

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria Dec 31, 2023
Epilepsy is a chronic disease of the brain characterized by seizures. The currently available anticonvulsants only treat symptoms with serious adverse drug reactions. Therefore, there is need for new therapeutic intervention that will prevent epilept...
Anticonvulsants Mice Anti-Inflammatory Agents Neuroprotective Agents Animals Cytokines Pentylenetetrazole Neuroinflammatory Diseases Disease Models, Animal Male Brain Seizures Quercetin
View on PubMed DOI

High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology.

Nature communications Dec 3, 2018
Technologies for mapping the spatial and temporal patterns of neural activity have advanced our understanding of brain function in both health and disease. An important application of these technologies is the discovery of next-generation neurotherap...
Animals, Genetically Modified Convulsants Neuropharmacology Drug Evaluation, Preclinical Zebrafish Disease Models, Animal Brain Mapping Pentylenetetrazole Seizures Molecular Structure Animals Larva Machine Learning Brain
View on PubMed DOI

Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy.

Journal of neuroscience methods Jun 1, 2017
BACKGROUND: Epilepsy is a chronic neurological condition, with over 30% of cases unresponsive to treatment. Zebrafish larvae show great potential to serve as an animal model of epilepsy in drug discovery. Thanks to their high fecundity and relatively...
Automation, Laboratory Sensitivity and Specificity Animals Pentylenetetrazole Brain Seizures Disease Models, Animal Zebrafish Electroencephalography Signal Processing, Computer-Assisted Pattern Recognition, Automated Larva Support Vector Machine Epilepsy
View on PubMed DOI

Rongchang and Xifeng capsules suppress pentylenetetrazole-induced seizures and change rest/wake behavior in zebrafish larvae.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Dec 1, 2019
OBJECTIVE: To evaluate the effects of Rongchang capsule and Xifeng capsule on pentylenetetrazole- induced epilepsy in zebrafish larvae and to explore the possible mechanisms behind their actions.
Rest Zebrafish Wakefulness Larva Seizures Animals Drugs, Chinese Herbal Anticonvulsants Male Pentylenetetrazole
View on PubMed
Popular Topics
Recent Journals