MRI-Based Machine Learning Prediction Framework to Lateralize Hippocampal Sclerosis in Patients With Temporal Lobe Epilepsy.

Journal: Neurology
PMID:

Abstract

BACKGROUND AND OBJECTIVES: MRI fails to reveal hippocampal pathology in 30% to 50% of temporal lobe epilepsy (TLE) surgical candidates. To address this clinical challenge, we developed an automated MRI-based classifier that lateralizes the side of covert hippocampal pathology in TLE.

Authors

  • Benoit Caldairou
    From the Neuroimaging of Epilepsy Laboratory (R.S.G., H.-M.L., B.C., S.-J.H., N.B., A.B.), Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada; Pediatric Neurology Unit and Laboratories (C.B., M.L., R.G.), Children's Hospital A. Meyer-University of Florence, Italy; Epilepsy Unit (F.D.) and Neuroradiology (L.D.), Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy; Department of Neurology (V.C.M.C., F.C.), University of Campinas, Brazil; The Florey Institute of Neuroscience and Mental Health and The University of Melbourne (M.S., G.J.), Victoria, Australia; Department of Pediatrics (D.V.S.), British Columbia Children's Hospital, Vancouver, Canada; Aix Marseille University (F.B.), INSERM UMR 1106, Institut de Neurosciences des Systèmes; Aix Marseille University (M.G.), CNRS, CRMBM UMR 7339, Marseille, France; Freiburg Epilepsy Center (A.S.-B., H.U.), Universitätsklinikum Freiburg, Germany; Department of Neurology (K.H.C.), Yonsei University College of Medicine, Seoul, Korea; and Department of Neurology (R.E.H.), Washington University School of Medicine, St. Louis, MO.
  • Niels A Foit
    From the Neuroimaging of Epilepsy Laboratory (B.C., N.A.F., C.M., F.F., R.G., H.M.L., A.B., N.B.), McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Quebec, Canada; and Departments of Neurosurgery (N.A.F.) and Neuroradiology (T.D., H.U.), Freiburg Medical Center, and Department of Neurology (A.S.-B.), University of Freiburg, Germany.
  • Carlotta Mutti
    From the Neuroimaging of Epilepsy Laboratory (B.C., N.A.F., C.M., F.F., R.G., H.M.L., A.B., N.B.), McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Quebec, Canada; and Departments of Neurosurgery (N.A.F.) and Neuroradiology (T.D., H.U.), Freiburg Medical Center, and Department of Neurology (A.S.-B.), University of Freiburg, Germany.
  • Fatemeh Fadaie
    From the Neuroimaging of Epilepsy Laboratory (B.C., N.A.F., C.M., F.F., R.G., H.M.L., A.B., N.B.), McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Quebec, Canada; and Departments of Neurosurgery (N.A.F.) and Neuroradiology (T.D., H.U.), Freiburg Medical Center, and Department of Neurology (A.S.-B.), University of Freiburg, Germany.
  • Ravnoor Gill
    From the Neuroimaging of Epilepsy Laboratory (B.C., N.A.F., C.M., F.F., R.G., H.M.L., A.B., N.B.), McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Quebec, Canada; and Departments of Neurosurgery (N.A.F.) and Neuroradiology (T.D., H.U.), Freiburg Medical Center, and Department of Neurology (A.S.-B.), University of Freiburg, Germany.
  • Hyo Min Lee
    From the Neuroimaging of Epilepsy Laboratory (B.C., N.A.F., C.M., F.F., R.G., H.M.L., A.B., N.B.), McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Quebec, Canada; and Departments of Neurosurgery (N.A.F.) and Neuroradiology (T.D., H.U.), Freiburg Medical Center, and Department of Neurology (A.S.-B.), University of Freiburg, Germany.
  • Theo Demerath
    Department of Neuroradiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Horst Urbach
    Department of Neuroradiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Andreas Schulze-Bonhage
  • Andrea Bernasconi
    Evidence-based Public Health, Centre for International Health Protection, Robert Koch Institute, Berlin, Germany.
  • Neda Bernasconi
    McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal, QC, H3A2B4, Canada.