Dynamic prediction of renal survival among deeply phenotyped kidney transplant recipients using artificial intelligence: an observational, international, multicohort study.

Journal: The Lancet. Digital health
PMID:

Abstract

BACKGROUND: Kidney allograft failure is a common cause of end-stage renal disease. We aimed to develop a dynamic artificial intelligence approach to enhance risk stratification for kidney transplant recipients by generating continuously refined predictions of survival using updates of clinical data.

Authors

  • Marc Raynaud
    Paris Translational Research Centre for Organ Transplantation, INSERM, PARCC, Université de Paris, Paris, France.
  • Olivier Aubert
    Paris Translational Research Centre for Organ Transplantation, INSERM, PARCC, Université de Paris, Paris, France; Kidney Transplant Department, Necker Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
  • Gillian Divard
    Paris Translational Research Centre for Organ Transplantation, INSERM, PARCC, Université de Paris, Paris, France; Kidney Transplant Department, Necker Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
  • Peter P Reese
    Paris Translational Research Centre for Organ Transplantation, INSERM, PARCC, Université de Paris, Paris, France; Renal Electrolyte and Hypertension Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
  • Nassim Kamar
    Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.
  • Daniel Yoo
    Paris Translational Research Centre for Organ Transplantation, INSERM, PARCC, Université de Paris, Paris, France.
  • Chen-Shan Chin
    Deep Learning in Medicine and Genomics, DNAnexus, San Francisco, CA, USA.
  • Elodie Bailly
    Service de Néphrologie-Hypertension, Dialyses, Transplantation Rénale, Hôpital Bretonneau, CHU Tours, Tours, France.
  • Matthias Büchler
    Service de Néphrologie-Hypertension, Dialyses, Transplantation Rénale, Hôpital Bretonneau, CHU Tours, Tours, France.
  • Marc Ladrière
    Nephrology Dialysis Transplantation Department, University of Lorraine, Centre Hospitalier Universitaire Nancy, Nancy, France.
  • Moglie Le Quintrec
    Department of Nephrology, Centre Hospitalier Universitaire Montpellier, Montpellier, France.
  • Michel Delahousse
    Department of Transplantation, Nephrology and Clinical Immunology, Foch Hospital, Suresnes, France.
  • Ivana Juric
    Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, School of Medicine University of Zagreb, Zagreb, Croatia.
  • Nikolina Basic-Jukic
    Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, School of Medicine University of Zagreb, Zagreb, Croatia.
  • Marta Crespo
    Department of Nephrology, Hospital del Mar Barcelona, Spain.
  • Helio Tedesco Silva
    Hospital do Rim, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Kamilla Linhares
    Hospital do Rim, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Maria Cristina Ribeiro de Castro
    Renal Transplantation Service, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Gervasio Soler Pujol
    Unidad de Trasplante Renopancreas, Centro de Educacion Medica e Investigaciones Clinicas Buenos Aires, Buenos Aires, Argentina.
  • Jean-Philippe Empana
    Paris Translational Research Centre for Organ Transplantation, INSERM, PARCC, Université de Paris, Paris, France.
  • Camilo Ulloa
    Kidney Transplantation Department, Clinica Alemana de Santiago, Santiago, Chile.
  • Enver Akalin
    Renal Division Montefiore Medical Centre, Kidney Transplantation Program, Albert Einstein College of Medicine, NY, USA.
  • Georg Böhmig
    Division of Nephrology and Dialysis, Department of Medicine III, General Hospital Vienna, Vienna, Austria.
  • Edmund Huang
    Department of Medicine, Division of Nephrology, Comprehensive Transplant Centre, Cedars Sinai Medical Centre, Los Angeles, CA, USA.
  • Mark D Stegall
    Divisions of Transplantation surgery.
  • Andrew J Bentall
    William J von Liebig Centre for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA.
  • Robert A Montgomery
    New York University Langone Transplant Institute, New York, NY, USA.
  • Stanley C Jordan
    Department of Medicine, Division of Nephrology, Comprehensive Transplant Centre, Cedars Sinai Medical Centre, Los Angeles, CA, USA.
  • Rainer Oberbauer
    Nephrology, Medical University of Vienna, Vienna, Austria.
  • Dorry L Segev
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • John J Friedewald
    Kidney Transplantation Department, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Xavier Jouven
    Paris Translational Research Centre for Organ Transplantation, INSERM, PARCC, Université de Paris, Paris, France; Cardiology Department, European Georges Pompidou Hospital, Paris, France.
  • Christophe Legendre
    Paris Translational Research Centre for Organ Transplantation, INSERM, PARCC, Université de Paris, Paris, France; Kidney Transplant Department, Necker Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
  • Carmen Lefaucheur
    Paris Translational Research Centre for Organ Transplantation, INSERM, PARCC, Université de Paris, Paris, France; Kidney Transplant Department, Saint-Louis Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.
  • Alexandre Loupy
    Hôpital Necker, Paris, France.