Modular robotic platform for precision neurosurgery with a bio-inspired needle: System overview and first in-vivo deployment.

Journal: PloS one
PMID:

Abstract

Over the past 10 years, minimally invasive surgery (MIS) has shown significant benefits compared to conventional surgical techniques, with reduced trauma, shorter hospital stays, and shorter patient recovery times. In neurosurgical MIS procedures, inserting a straight tool (e.g. catheter) is common practice in applications ranging from biopsy and laser ablation, to drug delivery and fluid evacuation. How to handle tissue deformation, target migration and access to deep-seated anatomical structures remain an open challenge, affecting both the preoperative planning phase and eventual surgical intervention. Here, we present the first neurosurgical platform in the literature, able to deliver an implantable steerable needle for a range of diagnostic and therapeutic applications, with a short-term focus on localised drug delivery. This work presents the system's architecture and first in vivo deployment with an optimised surgical workflow designed for pre-clinical trials with the ovine model, which demonstrate appropriate function and safe implantation.

Authors

  • Riccardo Secoli
    The Mechatronics in Medicine Lab, Department of Mechanical Engineering, Imperial College London, London, United Kingdom.
  • Eloise Matheson
    The Mechatronics in Medicine Lab, Department of Mechanical Engineering, Imperial College London, London, United Kingdom.
  • Marlene Pinzi
    Mechatronics in Medicine Laboratory, Department of Mechanical Engineering, Imperial College, London, UK. marlene.pinzi16@imperial.ac.uk.
  • Stefano Galvan
    Mechatronics in Medicine Laboratory, Department of Mechanical Engineering, Imperial College, London, UK.
  • Abdulhamit Donder
    The Mechatronics in Medicine Lab, Department of Mechanical Engineering, Imperial College London, London, United Kingdom.
  • Thomas Watts
    The Mechatronics in Medicine Lab, Department of Mechanical Engineering, Imperial College London, London, United Kingdom.
  • Marco Riva
    Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  • Davide Danilo Zani
    Department of Veterinary Medicine, Universitá degli Studi di Milano, Lodi, Italy.
  • Lorenzo Bello
    Department of Oncology and Hematology-Oncology, Universitá degli Studi di Milano, Milan, Italy.
  • Ferdinando Rodriguez Y Baena
    Department of Mechanical Engineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK. Electronic address: f.rodriguez@imperial.ac.uk.