Machine learning analyses of highly-multiplexed immunofluorescence identifies distinct tumor and stromal cell populations in primary pancreatic tumors.

Journal: Cancer biomarkers : section A of Disease markers
Published Date:

Abstract

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a formidable challenge for patients and clinicians.

Authors

  • Krysten Vance
    Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
  • Alphan Alitinok
    Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, USA.
  • Seth Winfree
    Department of Medicine, Division of Nephrology and Hypertension, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Heather Jensen-Smith
    Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
  • Benjamin J Swanson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.
  • Paul M Grandgenett
    Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.
  • Kelsey A Klute
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
  • Daniel J Crichton
    Department of Biochemistry and Molecular Medicine, George Washington University, Washington, DC 20037, USA, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA, Center for Bioinformatics and Information Technology, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20892-9760, USA, NASA Jet Propulsion Laboratory, Pasadena, CA, USA, Division of Cancer Prevention, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20892-9760, USA, Wellcome Trust Sanger Institute, Cambridge, UK and McCormick Genomic and Proteomic Center, George Washington University, Washington, DC 20037, USA.
  • Michael A Hollingsworth
    Fred and Pamela Buffet Cancer Center, Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska.