Genome-wide association study-based prediction of atrial fibrillation using artificial intelligence.

Journal: Open heart
PMID: 35086918

Abstract

OBJECTIVE: We previously reported early-onset atrial fibrillation (AF) associated genetic loci among a Korean population. We explored whether the AF-associated single-nucleotide polymorphisms (SNPs) selected from the Genome-Wide Association Study (GWAS) of an external large cohort has a prediction power for AF in Korean population through a convolutional neural network (CNN).

Authors

  • Oh-Seok Kwon
    Cardiology, Yonsei University Health System, Seodaemun-gu, Seoul, Korea (the Republic of).
  • Myunghee Hong
    Cardiology, Yonsei University Health System, Seodaemun-gu, Seoul, Korea (the Republic of).
  • Tae-Hoon Kim
    Interaction Laboratory of Advanced Technology Research Center, Korea University of Technology and Education, Cheonan, Chungcheongnam-do 31253, Republic of Korea.
  • Inseok Hwang
    Cardiology, Yonsei University Health System, Seodaemun-gu, Seoul, Korea (the Republic of).
  • Jaemin Shim
    Cardiovascular Center, Korea University Medical Center, Seoul, Korea (the Republic of).
  • Eue-Keun Choi
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
  • Hong Euy Lim
    Cardiology, Hallym University Sacred Heart Hospital, Anyang, Gyeonggi-do, Korea (the Republic of).
  • Hee Tae Yu
    Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
  • Jae-Sun Uhm
    Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
  • Boyoung Joung
    Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. cby6908@yuhs.ac.
  • Seil Oh
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
  • Moon-Hyoung Lee
    Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
  • Young-Hoon Kim
    Department of Orthopedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • Hui-Nam Pak
    Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

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