AIMC Topic: Homeodomain Proteins

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Neural network conditioned to produce thermophilic protein sequences can increase thermal stability.

Scientific reports Apr 23, 2025
This work presents Neural Optimization for Melting-temperature Enabled by Leveraging Translation (NOMELT), a novel approach for designing and ranking high-temperature stable proteins using neural machine translation. The model, trained on over 4 mill...
Amino Acid Sequence Protein Stability Drosophila Proteins Drosophila melanogaster Homeodomain Proteins Neural Networks, Computer Temperature Animals Transcription Factors
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Identification and validation of HOXC6 as a diagnostic biomarker for Ewing sarcoma: insights from machine learning algorithms and experiments.

Frontiers in immunology Apr 4, 2025
INTRODUCTION: Early diagnosis of Ewing sarcoma (ES) is critical for improving patient prognosis. However, the accurate diagnosis of ES remains challenging, underscoring the need for novel diagnostic biomarkers to enhance diagnostic precision and reli...
Cell Movement Bone Neoplasms Homeodomain Proteins Sarcoma, Ewing Gene Expression Profiling Cell Line, Tumor Gene Expression Regulation, Neoplastic Cell Proliferation Machine Learning Reproducibility of Results Humans Biomarkers, Tumor
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Integrating Machine Learning and Mendelian Randomization Determined a Functional Neurotrophin-Related Gene Signature in Patients with Lower-Grade Glioma.

Molecular biotechnology Jan 23, 2024
Recent researches reported that neurotrophins can promote glioma growth/invasion but the relevant model for predicting patients' survival in Lower-Grade Gliomas (LGGs) lacked. In this study, we adopted univariate Cox analysis, LASSO regression, and m...
Humans Machine Learning Prognosis Neoplasm Grading Proportional Hazards Models Gene Expression Regulation, Neoplastic Homeodomain Proteins Glioma Female Nerve Growth Factors DNA Copy Number Variations Sulfotransferases Brain Neoplasms Mendelian Randomization Analysis Male Polymorphism, Single Nucleotide
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HOX cluster and their cofactors showed an altered expression pattern in eutopic and ectopic endometriosis tissues.

Reproductive biology and endocrinology : RB&E Sep 1, 2021
Endometriosis is major gynecological disease that affects over 10% of women worldwide and 30%-50% of these women have pelvic pain, abnormal uterine bleeding and infertility. The cause of endometriosis is unknown and there is no definite cure mainly b...
Transcription Factors Endometrium Endometriosis Multigene Family Gene Ontology Homeodomain Proteins Genes, Homeobox Adult Gene Expression Profiling Gene Regulatory Networks Signal Transduction Humans Female Young Adult
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Machine learning approaches reveal subtle differences in breathing and sleep fragmentation in -derived astrocytes ablated mice.

Journal of neurophysiology Jan 27, 2021
Modern neurophysiology research requires the interrogation of high-dimensionality data sets. Machine learning and artificial intelligence (ML/AI) workflows have permeated into nearly all aspects of daily life in the developed world but have not been ...
Neurophysiology Machine Learning Genotype Animals Transcription Factors Gene Expression Profiling Respiration Astrocytes Mice Electroencephalography Homeodomain Proteins Workflow Plethysmography Sleep
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Carboxybetaine-modified succinylated chitosan-based beads encourage pancreatic β-cells (Min-6) to form islet-like spheroids under in vitro conditions.

Journal of materials science. Materials in medicine Dec 30, 2017
In vitro, pancreatic β-cells tend to reduce their ability to aggregate into islets and lose insulin-producing ability, likely due to insufficient cell-cell and cell-matrix interactions that are essential for β-cell retention, viability and functional...
Trans-Activators Betaine Homeodomain Proteins Scattering, Radiation Spheroids, Cellular Microscopy, Electron, Scanning Cadherins Surface Properties Animals Carbon Molecular Dynamics Simulation Cell Survival Insulin Insulin-Secreting Cells Insulin Secretion Chitosan Mice Cell Culture Techniques Lasers Spectroscopy, Fourier Transform Infrared Microscopy, Fluorescence
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Comparative analysis of weighted gene co-expression networks in human and mouse.

PloS one Nov 21, 2017
The application of complex network modeling to analyze large co-expression data sets has gained traction during the last decade. In particular, the use of the weighted gene co-expression network analysis framework has allowed an unbiased and systems-...
Sequence Homology Humans Retinoic Acid Receptor alpha Animals Gene Expression Profiling Gene Regulatory Networks Forkhead Transcription Factors Tissue Distribution Mice Gene Expression Regulation Gene Ontology Genetic Association Studies Homeodomain Proteins Core Binding Factor Alpha 1 Subunit
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Genome-wide association study-based prediction of atrial fibrillation using artificial intelligence.

Open heart Jan 1, 2022
OBJECTIVE: We previously reported early-onset atrial fibrillation (AF) associated genetic loci among a Korean population. We explored whether the AF-associated single-nucleotide polymorphisms (SNPs) selected from the Genome-Wide Association Study (GW...
Middle Aged Genome-Wide Association Study Genetic Predisposition to Disease Polymorphism, Single Nucleotide Artificial Intelligence Republic of Korea Female Male Homeodomain Proteins Homeobox Protein PITX2 Transcription Factors DNA Morbidity Atrial Fibrillation Humans
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Uncovering tissue-specific binding features from differential deep learning.

Nucleic acids research Mar 18, 2020
Transcription factors (TFs) can bind DNA in a cooperative manner, enabling a mutual increase in occupancy. Through this type of interaction, alternative binding sites can be preferentially bound in different tissues to regulate tissue-specific expres...
Poisson Distribution RNA High-Throughput Nucleotide Sequencing Embryo, Mammalian Organ Specificity Protein Isoforms Binding Sites Homeodomain Proteins Protein Binding Mice Computational Biology Models, Genetic Gene Expression Regulation, Developmental Animals Chromatin Immunoprecipitation Deep Learning Branchial Region Myeloid Ecotropic Viral Integration Site 1 Protein
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