Antemortem CSF A42/A40 ratio predicts Alzheimer's disease pathology better than A42 in rapidly progressive dementias.

Journal: Annals of clinical and translational neurology
Published Date: Dec 14, 2018

Abstract

OBJECTIVE: Despite the critical importance of pathologically confirmed samples for biomarker validation, only a few studies have correlated CSF A42 values in vivo with postmortem Alzheimer's disease (AD) pathology, while none evaluated the CSF A42/A40 ratio. We compared CSF A42 and A42/A40 ratio as biomarkers predicting AD neuropathological changes in patients with a short interval between lumbar puncture and death.

Authors

  • Simone Baiardi
    Department of Biomedical and Neuromotor Sciences University of Bologna Bologna 40123 Italy.
  • Samir Abu-Rumeileh
    Department of Biomedical and Neuromotor Sciences University of Bologna Bologna 40123 Italy.
  • Marcello Rossi
    IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna 40139 Italy.
  • Corrado Zenesini
    IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna 40139 Italy.
  • Anna Bartoletti-Stella
    IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna 40139 Italy.
  • Barbara Polischi
    IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna 40139 Italy.
  • Sabina Capellari
    Department of Biomedical and Neuromotor Sciences University of Bologna Bologna 40123 Italy.
  • Piero Parchi
    IRCCS Istituto delle Scienze Neurologiche di Bologna Bologna 40139 Italy.

Keywords

External Resources

Popular Topics
Recent Journals