Tauopathies are characterised by a progressive accumulation of hyperphosphorylated tau. However, early and intermediate stages remain challenging to quantify due to subtle and heterogeneous morphological characteristics. This study evaluates a deep l...
Antibody transistor biosensors show promise for early Alzheimer's disease (AD) diagnosis due to their single molecule detection capability. However, the random attachment of a payload to antigen-binding fragments (Fab) during biosensor preparation ca...
Accurate subcellular segmentation is crucial for understanding cellular processes, but traditional methods struggle with noise and complex structures. Convolutional neural networks improve accuracy but require large, time-consuming, and biased manual...
Progressive supranuclear palsy (PSP) is a rare and debilitating four-repeat (4R) tauopathy, characterized by motor dysfunction, cognitive decline, and oculomotor abnormalities, yet it lacks reliable biomarkers for early diagnosis, disease stratificat...
BACKGROUND AND OBJECTIVES: The choroid plexus (ChP) plays a crucial role in maintaining brain health. Alzheimer disease (AD) pathologies may damage the ChP and accelerate neurodegeneration. Previous imaging studies have found overall increased ChP vo...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Nov 3, 2025
We developed and evaluated an artificial intelligence (AI)-powered approach for easier quantification of tau PET uptake without requiring structural MR to aid earlier tracking of Alzheimer disease (AD). We implemented a deep neural network model tha...
Early diagnosis of Alzheimer's disease (AD) requires blood biomarker tests sensitive to femtogram/mL concentrations. Graphene field-effect transistors (GFETs) are promising for this application, but suffer from device-to-device variability and requir...
INTRODUCTION: Quantification of amyloid plaques (A), neurofibrillary tangles (T), and neurodegeneration (N) using PET and MRI is critical for Alzheimer's disease (AD) diagnosis and prognosis. Existing pipelines face limitations regarding processing t...
Alzheimer's disease is a progressive neurodegenerative disorder with no cure, making preventive strategies crucial. Dietary interventions, particularly the Mediterranean (MeDi) and MIND diets, have been associated with reduced cognitive decline, but ...
BACKGROUND AND OBJECTIVES: Early and cost-effective identification of amyloid positivity is crucial for Alzheimer's disease (AD) diagnosis. While amyloid PET is the gold standard, plasma biomarkers such as phosphorylated tau 217 (pTau217) provide a p...
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