AIMC Topic: Amyloid beta-Peptides
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AI-driven fusion of multimodal data for Alzheimer's disease biomarker assessment.
Nature communications
Aug 11, 2025
Alzheimer's disease (AD) diagnosis hinges on detecting amyloid beta (Aβ) plaques and neurofibrillary tau (τ) tangles, typically assessed using PET imaging. While accurate, these modalities are expensive and not widely accessible, limiting their utili...
Machine-learning based strategy identifies a robust protein biomarker panel for Alzheimer's disease in cerebrospinal fluid.
Alzheimer's research & therapy
Jul 4, 2025
BACKGROUND: The complex pathogenesis of Alzheimer's disease (AD) has resulted in limited current biomarkers for its classification and diagnosis, necessitating further investigation into reliable universal biomarkers or combinations.
Machine learning model for predicting Amyloid-β positivity and cognitive status using early-phase F-Florbetaben PET and clinical features.
Scientific reports
Jul 1, 2025
This study developed machine learning models to predict Aβ positivity in Alzheimer's disease by integrating early-phase F-Florbetaben PET and clinical data to improve diagnostic accuracy. Furthermore, the study explored machine learning models to pre...
A Robust Residual Three-dimensional Convolutional Neural Networks Model for Prediction of Amyloid-β Positivity by Using FDG-PET.
Clinical nuclear medicine
Jun 17, 2025
BACKGROUND: Widely used in oncology PET, 2-deoxy-2- 18 F-FDG PET is more accessible and affordable than amyloid PET, which is a crucial tool to determine amyloid positivity in diagnosis of Alzheimer disease (AD). This study aimed to leverage deep lea...
Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state.
Science advances
Jun 11, 2025
Amyloid aggregates are pathological hallmarks of many human diseases, but how soluble proteins nucleate to form amyloids is poorly understood. Here, we use combinatorial mutagenesis, a kinetic selection assay, and machine learning to massively pertur...
An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates.
Nature communications
Jun 4, 2025
Mitophagy, the selective autophagic elimination of mitochondria, is essential for maintaining mitochondrial quality and cell homeostasis. Impairment of mitophagy flux, a process involving multiple sequential intermediates, is implicated in the onset ...
Role of astroglia and microglia in Alzheimer's disease and multiple therapeutic interventions.
Journal of Alzheimer's disease : JAD
Jun 2, 2025
Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) and neurofibrillary tangles (NFTs) formed by aggregates of hyperphosphorylated tau proteins. It presents a formidable global health challenge, prompting the exploration of inno...
In Silico Screening of Small Molecule Inhibitors for Amyloid-β Aggregation.
Journal of chemical information and modeling
May 29, 2025
The self-aggregation of amyloid-β (Aβ) into fibrils is a hallmark of Alzheimer's disease (AD). Inhibition of Aβ aggregation with small molecule compounds represents a promising therapeutic strategy for AD. However, designing effective ligands is chal...
Cerebrospinal fluid inflammatory cytokines as prognostic indicators for cognitive decline across Alzheimer's disease spectrum.
Journal of Alzheimer's disease : JAD
Apr 22, 2025
BackgroundNeuroinflammation actively contributes to the pathophysiology of Alzheimer's disease (AD); however, the value of neuroinflammatory biomarkers for disease-staging or predicting disease progression remains unclear.ObjectiveTo investigate diag...
Machine Learning Interpretation of Optical Spectroscopy Using Peak-Sensitive Logistic Regression.
ACS nano
Apr 15, 2025
Optical spectroscopy, a noninvasive molecular sensing technique, offers valuable insights into material characterization, molecule identification, and biosample analysis. Despite the informativeness of high-dimensional optical spectra, their interpre...
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