A metabolomics-based approach for non-invasive screening of fetal central nervous system anomalies.

Journal: Metabolomics : Official journal of the Metabolomic Society
PMID: 30830338

Abstract

BACKGROUND: Central nervous system anomalies represent a wide range of congenital birth defects, with an incidence of approximately 1% of all births. They are currently diagnosed using ultrasound evaluation. However, there is strong need for a more accurate and less operator-dependent screening method.

Authors

  • Jacopo Troisi
    Department of Medicine and Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Fisciano, Italy. troisi@theoreosrl.com.
  • Annamaria Landolfi
    Department of Medicine and Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Fisciano, Italy.
  • Laura Sarno
    Department of Neurosciences and Reproductive and Dentistry Sciences, University of Naples Federico II, Naples, Italy.
  • Sean Richards
    Department of Biology, Geology and Environmental Sciences, University of Tennessee at Chattanooga, 615 McCallie Ave., Chattanooga, TN, 37403, USA.
  • Steven Symes
    Department of Chemistry and Physics, University of Tennessee at Chattanooga, 615 McCallie Ave., Chattanooga, TN, 37403, USA.
  • David Adair
    Department of Obstetrics and Gynecology, University of Tennessee College of Medicine, Chattanooga, TN, USA.
  • Carla Ciccone
    "G. Moscati" Hospital, Avellino, Italy.
  • Giovanni Scala
    Theoreo srl - Spin-off company of the University of Salerno, Via S. De Renzi, 50., Salerno, Italy.
  • Pasquale Martinelli
    Department of Neurosciences and Reproductive and Dentistry Sciences, University of Naples Federico II, Naples, Italy.
  • Maurizio Guida
    Department of Medicine and Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Fisciano, Italy.

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