Machine Learning Used to Compare the Diagnostic Accuracy of Risk Factors, Clinical Signs and Biomarkers and to Develop a New Prediction Model for Neonatal Early-onset Sepsis.

Journal: The Pediatric infectious disease journal
PMID:

Abstract

BACKGROUND: Current strategies for risk stratification and prediction of neonatal early-onset sepsis (EOS) are inefficient and lack diagnostic performance. The aim of this study was to use machine learning to analyze the diagnostic accuracy of risk factors (RFs), clinical signs and biomarkers and to develop a prediction model for culture-proven EOS. We hypothesized that the contribution to diagnostic accuracy of biomarkers is higher than of RFs or clinical signs.

Authors

  • Martin Stocker
    From the Department of Paediatrics, Neonatal and Paediatric Intensive Care Unit, Children's Hospital Lucerne, Lucerne.
  • Imant Daunhawer
    Adaptive Systems and Medical Data Science, Department of Mathematics and Computer Science, University of Basel, Basel, Switzerland.
  • Wendy van Herk
    Department of Paediatrics, Division of Paediatric Infectious Diseases and Immunology, Erasmus MC University Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Salhab El Helou
    Division of Neonatology, McMaster University Children's Hospital, Hamilton Health Sciences, Hamilton, ON, Canada.
  • Sourabh Dutta
    Division of Neonatology, McMaster University Children's Hospital, Hamilton Health Sciences, Hamilton, ON, Canada.
  • Frank A B A Schuerman
    Department of Neonatal Intensive Care Unit, Isala Women and Children's Hospital, Zwolle.
  • Rita K van den Tooren-de Groot
    Department of Paediatrics, Haaglanden Medical Centre, 's Gravenhage, The Netherlands.
  • Jantien W Wieringa
    Department of Paediatrics, Haaglanden Medical Centre, 's Gravenhage, The Netherlands.
  • Jan Janota
    Department of Obstetrics and Gynecology, Motol University Hospital, Second Medical Faculty, Prague, Czech Republic.
  • Laura H van der Meer-Kappelle
    Department of Neonatology, Reinier de Graaf Gasthuis, Delft.
  • Rob Moonen
    Department of Neonatology, Zuyderland Medical Centre, Heerlen.
  • Sintha D Sie
    Department of Neonatology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam.
  • Esther de Vries
    Department of Jeroen Bosch Academy Research, Jeroen Bosch Hospital, 's-Hertogenbosch.
  • Albertine E Donker
    Department of Paediatrics, Maxima Medical Centre, Veldhoven, The Netherlands.
  • Urs Zimmerman
    Department of Paediatrics, Kantonsspital Winterthur, Winterthur.
  • Luregn J Schlapbach
    Neonatal and Pediatric Intensive Care Unit, Children`s Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
  • Amerik C de Mol
    Department of Neonatology, Albert Schweitzer Hospital, Dordrecht.
  • Angelique Hoffmann-Haringsma
    Department of Neonatology, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
  • Madan Roy
    Department of Neonatology, St. Josephs Healthcare, Hamilton Health Sciences, Hamilton, ON, Canada.
  • Maren Tomaske
    Department of Paediatrics, Stadtspital Triemli, Zürich, Switzerland.
  • René F Kornelisse
    Department of Paediatrics, Division of Neonatology, Erasmus MC University Medical Centre-Sophia Children's Hospital, Rotterdam.
  • Juliette van Gijsel
    Therapeuticum Utrecht, Utrecht.
  • Frans B Plötz
    Department of Pediatrics, Tergooi Hospital, Blaricum, the Netherlands and Amsterdam University Medical Center, Department of Pediatrics, Amsterdam, The Netherlands.
  • Sven Wellmann
    Division of Neonatology, University of Basel Children's Hospital (UKBB), Basel, Switzerland. sven.wellmann@ukbb.ch.
  • Niek B Achten
    Department of Pediatrics, Tergooi Hospital, Blaricum, the Netherlands and Amsterdam University Medical Center, Department of Pediatrics, Amsterdam, The Netherlands.
  • Dirk Lehnick
    Department of Health Sciences and Medicine, Head Biostatistics and Methodology, University of Lucerne, Lucerne, Switzerland.
  • Annemarie M C van Rossum
    Department of Paediatrics, Division of Paediatric Infectious Diseases and Immunology, Erasmus MC University Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Julia E Vogt