Synbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial.

Journal: Food research international (Ottawa, Ont.)
PMID: 30716942

Abstract

Generation of uremic toxins p-cresylsulfate (p-CS), indoxyl sulfate (IS) and indole 3-acetic acid (IAA) in hemodialysis (HD) individuals may be associated with the gut flora and recognized markers of disease progression. This study investigated the effect of synbiotic meal on uremic toxins in HD individuals. We conducted randomized singleblind and placebo-controlled intervention study with 58 HD subjects (20F/38M, 63.1 ± 10.9-old) who were randomly allocated in synbiotic group (SG, 40 g of extruded sorghum plus 100 mL of unfermented probiotic milk) or control group (CG, 40 g of extruded corn plus 100 mL of pasteurized milk), during 7-wk Metabolic markers and uremic toxins, fecal concentration of short chain fatty acid and pH value was determined. The SG group had decreased serum p-CS and IS, as well as decreased urea concentration (p < .05) compared to CG. SG showed higher fecal butyric acid and lower pH compared to baseline and SC (p < .05). In addition, serum p-CS and fecal pH were positively correlated to urea concentration in SG participants at the endpoint. The consumption of the synbiotic meal during 7-wk reduced colonic pH, and reduced serum uremic (p-CS and IS) toxins and urea in HD subjects.

Authors

  • Rita de Cássia Stampini Oliveira Lopes
    Nutrition and Health Department, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa 36.570-900, Minas Gerais, Brazil. Electronic address: rita.lopes@ufv.br.
  • Jaqueline Maciel Vieira Theodoro
    Nutrition and Health Department, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa 36.570-900, Minas Gerais, Brazil.
  • Bárbara Pereira da Silva
    Nutrition and Health Department, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa 36.570-900, Minas Gerais, Brazil.
  • Valéria Aparecida Vieira Queiroz
    Embrapa Maize and Sorghum, Rodovia MG 424, Km 65, 35.701-970 Sete Lagoas, Minas Gerais, Brazil.
  • Maria Eliza de Castro Moreira
    Nutrition and Health Department, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa 36.570-900, Minas Gerais, Brazil.
  • Hilário Cuquetto Mantovani
    Microbiology Department, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa 36.570-900, Minas Gerais, Brazil.
  • Helen Hermana Hermsdorff
    Nutrition and Health Department, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa 36.570-900, Minas Gerais, Brazil.
  • Hércia Stampini Duarte Martino
    Nutrition and Health Department, Federal University of Viçosa, PH Rolfs Avenue, s/n, Viçosa 36.570-900, Minas Gerais, Brazil.

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