AIMC Topic: Uremia

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Integrated bioinformatics and machine learning reveal key genes and immune mechanisms associated with uremia.

Scientific reports Jul 14, 2025
Uremia is a serious complication of end-stage chronic kidney disease, closely associated with immune imbalance and chronic inflammation. However, its molecular mechanisms remain largely unclear. In this study, we analyzed transcriptomic data from the...
Humans Machine Learning Gene Expression Profiling Transcriptome ROC Curve Gene Regulatory Networks Computational Biology Databases, Genetic Uremia
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Synbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial.

Food research international (Ottawa, Ont.) Aug 9, 2018
Generation of uremic toxins p-cresylsulfate (p-CS), indoxyl sulfate (IS) and indole 3-acetic acid (IAA) in hemodialysis (HD) individuals may be associated with the gut flora and recognized markers of disease progression. This study investigated the e...
Humans Biomarkers Female Aged Male Middle Aged Brazil Renal Dialysis Renal Insufficiency, Chronic Gastrointestinal Microbiome Probiotics Hydrogen-Ion Concentration Indican Meals Bifidobacterium longum Cresols Indoleacetic Acids Sulfuric Acid Esters Synbiotics Urea Uremia
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HEPNet: A Knowledge Base Model of Human Energy Pool Network for Predicting the Energy Availability Status of an Individual.

PloS one Jun 8, 2015
HEPNet is an electronic representation of metabolic reactions occurring within human cellular organization focusing on inflow and outflow of the energy currency ATP, GTP and other energy associated moieties. The backbone of HEPNet consists of primary...
Humans Computer Simulation Reproducibility of Results Glucose Models, Biological Knowledge Bases Adenosine Triphosphate Energy Metabolism Semantics Uremia NAD Acyl Coenzyme A Carnitine Ketoglutaric Acids Phosphocreatine
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