Neurotoxicity of intraneural injection of bupivacaine liposome injectable suspension versus bupivacaine hydrochloride in a porcine model.

Journal: Veterinary anaesthesia and analgesia
PMID: 30711466

Abstract

OBJECTIVE: To test whether neurotoxic effects of a bupivacaine liposome injectable suspension differ from those of a standard formulation of bupivacaine hydrochloride (HCl) after intraneural injection into the sciatic nerves in pigs.

Authors

  • Marija Damjanovska
    Clinical Department of Anesthesiology and Intensive Therapy, University Medical Centre Ljubljana, Ljubljana, Slovenia. Electronic address: marijadamjanovska@gmail.com.
  • Erika Cvetko
    Institute of Anatomy, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Maxine M Kuroda
    NYSORA, The New York School of Regional Anesthesia, New York, NY, USA; SciMedBE, Genk, Belgium.
  • Alenka Seliskar
    Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia.
  • Tanja Plavec
    Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia.
  • Katarina Mis
    Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Matej Podbregar
    Clinical Department of Anesthesiology and Intensive Therapy, University Medical Centre Ljubljana, Ljubljana, Slovenia.
  • Tatjana Stopar Pintaric
    Clinical Department of Anesthesiology and Intensive Therapy, University Medical Centre Ljubljana, Ljubljana, Slovenia; Institute of Anatomy, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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