Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy.

Journal: Frontiers in cellular and infection microbiology
PMID: 39902185

Abstract

Messenger RNA (mRNA) vaccines offer an adaptable and scalable platform for cancer immunotherapy, requiring optimal design to elicit a robust and targeted immune response. Recent advancements in bioinformatics and artificial intelligence (AI) have significantly enhanced the design, prediction, and optimization of mRNA vaccines. This paper reviews technologies that streamline mRNA vaccine development, from genomic sequencing to lipid nanoparticle (LNP) formulation. We discuss how accurate predictions of neoantigen structures guide the design of mRNA sequences that effectively target immune and cancer cells. Furthermore, we examine AI-driven approaches that optimize mRNA-LNP formulations, enhancing delivery and stability. These technological innovations not only improve vaccine design but also enhance pharmacokinetics and pharmacodynamics, offering promising avenues for personalized cancer immunotherapy.

Authors

  • Saber Imani
    Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, China.
  • Xiaoyan Li
    Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, China.
  • Keyi Chen
    Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, China.
  • Mazaher Maghsoudloo
    Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan, China.
  • Parham Jabbarzadeh Kaboli
    Department of Biochemistry, Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.
  • Mehrdad Hashemi
    Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
  • Saloomeh Khoushab
    Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
  • Xiaoping Li
    Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang, China.

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