AIMC Topic: Vaccines, Synthetic

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Harnessing Computational Strategies to Overcome Challenges in mRNA Vaccines.

Physiology (Bethesda, Md.) Mar 10, 2025
In recent years, the introduction of mRNA vaccines for SARS-CoV2 and respiratory syncytial virus (RSV) has highlighted the success of the mRNA technology platform. Designing mRNA sequences involves multiple components and requires balancing several p...
Computational Biology mRNA Vaccines COVID-19 COVID-19 Vaccines Animals SARS-CoV-2 Humans Vaccines, Synthetic Nanoparticles Vaccine Development RNA, Messenger
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Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy.

Frontiers in cellular and infection microbiology Jan 20, 2025
Messenger RNA (mRNA) vaccines offer an adaptable and scalable platform for cancer immunotherapy, requiring optimal design to elicit a robust and targeted immune response. Recent advancements in bioinformatics and artificial intelligence (AI) have sig...
RNA, Messenger Vaccine Development mRNA Vaccines Computational Biology Nanoparticles Vaccines, Synthetic Antigens, Neoplasm Cancer Vaccines Artificial Intelligence Humans Immunotherapy Neoplasms
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and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes.

The Journal of biological chemistry May 23, 2017
Tumor exomes provide comprehensive information on mutated, overexpressed genes and aberrant splicing, which can be exploited for personalized cancer immunotherapy. Of particular interest are mutated tumor antigen T-cell epitopes, because neoepitope-s...
Protein Stability Expert Systems HLA-A2 Antigen Mice, Transgenic Models, Immunological Immunogenicity, Vaccine Oligopeptides Artificial Intelligence Mice, Knockout Humans Epitopes T-Lymphocytes, Cytotoxic Membrane Proteins Peptide Fragments Computational Biology Protein Refolding Melanoma Vaccines, Synthetic Antigens, Neoplasm Neoplasm Proteins Cancer Vaccines Reproducibility of Results Animals Cells, Cultured
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Cloning Strategies for the Generation of Recombinant Capripoxvirus Through the Use of Screening and Selection Markers.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2022
The ability to manipulate capripoxvirus through gene knockouts and gene insertions has become an increasingly valuable research tool in elucidating the function of individual genes of capripoxvirus, as well as in the development of capripoxvirus-base...
Genes, Reporter Cloning, Molecular Capripoxvirus Vaccines, Synthetic Escherichia coli
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