AIMC Topic: Vaccines, Synthetic
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Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy.
Frontiers in cellular and infection microbiology
Jan 20, 2025
Messenger RNA (mRNA) vaccines offer an adaptable and scalable platform for cancer immunotherapy, requiring optimal design to elicit a robust and targeted immune response. Recent advancements in bioinformatics and artificial intelligence (AI) have sig...
and cell-based analyses reveal strong divergence between prediction and observation of T-cell-recognized tumor antigen T-cell epitopes.
The Journal of biological chemistry
May 23, 2017
Tumor exomes provide comprehensive information on mutated, overexpressed genes and aberrant splicing, which can be exploited for personalized cancer immunotherapy. Of particular interest are mutated tumor antigen T-cell epitopes, because neoepitope-s...
Humans
Artificial Intelligence
Cells, Cultured
Melanoma
Reproducibility of Results
Animals
Computational Biology
Cancer Vaccines
Antigens, Neoplasm
Vaccines, Synthetic
Membrane Proteins
Neoplasm Proteins
Mice, Knockout
Peptide Fragments
Epitopes
HLA-A2 Antigen
Protein Stability
Expert Systems
Oligopeptides
Immunogenicity, Vaccine
Mice, Transgenic
Models, Immunological
Protein Refolding
T-Lymphocytes, Cytotoxic
Cloning Strategies for the Generation of Recombinant Capripoxvirus Through the Use of Screening and Selection Markers.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2022
The ability to manipulate capripoxvirus through gene knockouts and gene insertions has become an increasingly valuable research tool in elucidating the function of individual genes of capripoxvirus, as well as in the development of capripoxvirus-base...
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