AIMC Topic: mRNA Vaccines
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Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy.
Frontiers in cellular and infection microbiology
Jan 20, 2025
Messenger RNA (mRNA) vaccines offer an adaptable and scalable platform for cancer immunotherapy, requiring optimal design to elicit a robust and targeted immune response. Recent advancements in bioinformatics and artificial intelligence (AI) have sig...
Rational Design of Lipid Nanoparticles for Enhanced mRNA Vaccine Delivery via Machine Learning.
Small (Weinheim an der Bergstrasse, Germany)
Sep 12, 2024
Since the coronavirus pandemic, mRNA vaccines have revolutionized the field of vaccinology. Lipid nanoparticles (LNPs) are proposed to enhance mRNA delivery efficiency; however, their design is suboptimal. Here, a rational method for designing LNPs i...
AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA delivery.
Nature communications
Jul 26, 2024
Ionizable lipid nanoparticles (LNPs) are seeing widespread use in mRNA delivery, notably in SARS-CoV-2 mRNA vaccines. However, the expansion of mRNA therapies beyond COVID-19 is impeded by the absence of LNPs tailored for diverse cell types. In this ...
Predicting humoral responses to primary and booster SARS-CoV-2 mRNA vaccination in people living with HIV: a machine learning approach.
Journal of translational medicine
May 7, 2024
BACKGROUND: SARS-CoV-2 mRNA vaccines are highly immunogenic in people living with HIV (PLWH) on effective antiretroviral therapy (ART). However, whether viro-immunologic parameters or other factors affect immune responses to vaccination is debated. T...
Comparative study of lipid nanoparticle-based mRNA vaccine bioprocess with machine learning and combinatorial artificial neural network-design of experiment approach.
International journal of pharmaceutics
May 2, 2023
To develop a combinatorial artificial-neural-network design-of-experiment (ANN-DOE) model, the effect of ionizable lipid, an ionizable lipid-to-cholesterol ratio, N/P ratio, flow rate ratio (FRR), and total flow rate (TFR) on the outcome responses of...
Literature Mining and Mechanistic Graphical Modelling to Improve mRNA Vaccine Platforms.
Frontiers in immunology
Sep 7, 2021
RNA vaccines represent a milestone in the history of vaccinology. They provide several advantages over more traditional approaches to vaccine development, showing strong immunogenicity and an overall favorable safety profile. While preclinical testin...
Artificial Intelligence for Vaccine Design.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2022
Often likened to "the new electricity," artificial intelligence (AI) has broad and sweeping impact in many areas. Perhaps most exciting among these are in bioinformatics as AI allows for new and increasingly powerful ways of understanding genomics, p...
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