Combination of CDX2 H-score quantitative analysis with CD3 AI-guided analysis identifies patients with a good prognosis only in stage III colon cancer.

Journal: European journal of cancer (Oxford, England : 1990)
PMID:

Abstract

AIM: Stratification of colon cancer (CC) of patients with stage II and III for risk of relapse is still needed especially to drive adjuvant therapy administration. Our study evaluates the prognostic performance of two known biomarkers, CDX2 and CD3, standalone or their combined information in stage II and III CC.

Authors

  • Valentin Derangere
    Plateforme de recherche biologique en oncologie, Georges-Francois Leclerc Centre, Dijon, Bourgogne-Franche-Comté, France.
  • Julie Lecuelle
    Centre de Recherche INSERM LNC-UMR1231, F-21000 Dijon, France; University of Burgundy Franche-Comté, F-21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, F-21000 Dijon, France.
  • Come Lepage
    Département d'hépato-gastroentérologie et en oncologie digestive, Hôpital du Bocage, Dijon, Bourgogne-Franche-Comté, France.
  • Oumaima Aoulad-Ben Salem
    Centre de Recherche INSERM LNC-UMR1231, F-21000 Dijon, France; University of Burgundy Franche-Comté, F-21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, F-21000 Dijon, France.
  • Ben M Allatessem
    Centre de Recherche INSERM LNC-UMR1231, F-21000 Dijon, France; University of Burgundy Franche-Comté, F-21000 Dijon, France; Cancer Biology Transfer Platform, Centre Georges-François Leclerc, F-21000 Dijon, France.
  • Alis Ilie
    Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-UNICANCER, 1 rue du Professeur Marion, 21000, Dijon, France.
  • Olivier Bouché
    CHU Robert Debré, Médecine Ambulatoire-Cancérologie, Reims, France.
  • Jean-Marc Phelip
    Service D'Hépatogastro-entérologie - CHU de Saint Etienne - Hôpital Nord, Saint-Etienne, France.
  • Mathieu Baconnier
    Centre Hospitalier Annecy Genevois Service HGE, Pringy, France.
  • Denis Pezet
    Digestive and Hepatobiliary Surgery Department, University of Auvergne, University Hospital Estaing, Clermont-Ferrand, France.
  • Virginie Sebbagh
    Centre Hospitalier de Compiègne, Service Gastro-entérologie et Hépatologie, Compiègne, France.
  • Eric Terrebonne
    Hôpital Haut Lévêque, Service d'HGE, PESSAC, France.
  • Gauthier Bouard
    Service D'Anatomie et Cytologie Pathologiques, CHU Côte de Nacre, Normandie Université, Caen, France.
  • Valérie Jooste
    Centre de Recherche INSERM LNC-UMR1231, F-21000 Dijon, France; University of Burgundy Franche-Comté, F-21000 Dijon, France; Digestive Cancer Registry of Burgundy, Dijon University Hospital, Dijon France.
  • Anne-Marie Bouvier
    Centre de Recherche INSERM LNC-UMR1231, F-21000 Dijon, France; University of Burgundy Franche-Comté, F-21000 Dijon, France; Digestive Cancer Registry of Burgundy, Dijon University Hospital, Dijon France.
  • Chloé Molimard
    CHU de Besançon, Service d'anatomie Pathologique, France.
  • Franck Monnien
    CHU de Besançon, Service d'anatomie Pathologique, France.
  • Daniel Gonzalez
    European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD UK ; Centre for Therapeutic Target Validation, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD UK.
  • Karine Le Malicot
    Fédération Francophone de Cancérologie Digestive, Hôpital du Bocage, Dijon, Bourgogne-Franche-Comté, France.
  • David Rageot
    Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-UNICANCER, 1 rue du Professeur Marion, 21000, Dijon, France.
  • Caroline Truntzer
    Platform of Transfer in Biological Oncology, Georges François Leclerc Cancer Center-UNICANCER, 1 rue du Professeur Marion, 21000, Dijon, France.
  • Frederic Bibeau
    Department of Pathology, Caen University Hospital, Normandy University, Caen, France.
  • François Ghiringhelli
    Département d'oncologie médicale, Georges-Francois Leclerc Centre, Dijon, Bourgogne-Franche-Comté, France fghiringhelli@cgfl.fr.