Selective cytotoxic and genotoxic activities of 5-(2-bromo-5-methoxybenzylidene)-thiazolidine-2,4-dione against NCI-H292 human lung carcinoma cells.

Journal: Pharmacological reports : PR
PMID: 29627691

Abstract

BACKGROUND: Thiazolidine-2,4-dione ring system is used as a pharmacophore to build various heterocyclic compounds aimed to interact with biological targets. In the present study, benzylidene-2,4-thiazolidinedione derivatives (compounds 2-5) were synthesized and screened against cancer cell lines and the genotoxicity and cytotoxicity of the most active compound (5) was investigated on normal and lung cancer cell line.

Authors

  • Maria do D Rodrigues
    Department of Antibiotics, Federal University of Pernambuco, Recife, PE, Brazil.
  • Priscila B G S Santiago
    Department of Antibiotics, Federal University of Pernambuco, Recife, PE, Brazil.
  • Karla M R Marques
    Department of Antibiotics, Federal University of Pernambuco, Recife, PE, Brazil.
  • Valéria R A Pereira
    Department of Immunology, Oswaldo Cruz Foundation, Aggeu Magalhães Research Center, Campus da UFPE, Recife, PE, Brazil.
  • Maria C A B de Castro
    Department of Immunology, Oswaldo Cruz Foundation, Aggeu Magalhães Research Center, Campus da UFPE, Recife, PE, Brazil; Academic Center of Vitoria, Federal University of Pernambuco, Parasitology Laboratory, Recife, PE, Brazil.
  • Jeanne C L L Cantalice
    Department of Antibiotics, Federal University of Pernambuco, Recife, PE, Brazil.
  • Teresinha G da Silva
    Department of Antibiotics, Federal University of Pernambuco, Recife, PE, Brazil.
  • Mônica L Adam
    Department of Biological Sciences, Academic Center of Victoria, Federal University of Pernambuco, Receife, PE, Brazil.
  • Silene C do Nascimento
    Department of Antibiotics, Federal University of Pernambuco, Recife, PE, Brazil.
  • Julianna F C de Albuquerque
    Department of Antibiotics, Federal University of Pernambuco, Recife, PE, Brazil.
  • Gardenia C G Militao
    Department of Physiology and Pharmacology, Federal University of Pernambuco, Recife, PE, Brazil. Electronic address: gcgadelha@yahoo.com.br.

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