AIMC Topic: Comet Assay
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Classification of DNA damages on segmented comet assay images using convolutional neural network.
Computer methods and programs in biomedicine
Nov 6, 2019
BACKGROUND AND OBJECTIVE: Identification and quantification of DNA damage is a very significant subject in biomedical research area which still needs more robust and effective methods. One of the cheapest, easy to use and most successful method for D...
Evaluating genotoxicity of metal oxide nanoparticles: Application of advanced supervised and unsupervised machine learning techniques.
Ecotoxicology and environmental safety
Sep 30, 2019
Presence of missing data points in datasets is among main challenges in handling the toxicological data for nanomaterials. As the processing of missing data is an important part of data analysis, we have introduced a read-across approach that uses a ...
Dry olive leaf extract attenuates DNA damage induced by estradiol and diethylstilbestrol in human peripheral blood cells in vitro.
Mutation research. Genetic toxicology and environmental mutagenesis
Dec 21, 2018
Phenolic groups of steroidal or nonsteroidal estrogens can redox cycle, leading to oxidative stress, where creation of reactive oxygen species are recognized as the main mechanism of their DNA damage properties. Dry olive (Olea europaea L.) leaf extr...
Comet Assay
Diethylstilbestrol
Estrogen Antagonists
Free Radical Scavengers
Drug Evaluation, Preclinical
Olea
Blood Cells
Antioxidants
Adult
Plant Extracts
Reactive Oxygen Species
Male
Dose-Response Relationship, Drug
Plant Leaves
Oxidation-Reduction
Oxidative Stress
DNA Damage
Humans
Estradiol
Female
Young Adult
Manganese oxide nanoparticles induce genotoxicity and DNA hypomethylation in the moss Physcomitrella patens.
Mutation research. Genetic toxicology and environmental mutagenesis
Dec 18, 2018
The genotoxicity of nanoparticles is a major concern for nano-safety appraisal in the bryophytes as they are the primary colonizers of bare land, indicators of atmospheric pollution and excellent accumulators of trace metals. The present study for th...
Investigation of genotoxic effects of paraben in cultured human lymphocytes.
Drug and chemical toxicology
Dec 27, 2017
Paraben is a phenolic derivative of benzoic acid extensively used as preservatives in food, pharmaceutical, and cosmetic industries due to its antimicrobial characteristics. The objective of this study was to evaluate the in vitro genotoxic effects o...
Selective cytotoxic and genotoxic activities of 5-(2-bromo-5-methoxybenzylidene)-thiazolidine-2,4-dione against NCI-H292 human lung carcinoma cells.
Pharmacological reports : PR
Nov 22, 2017
BACKGROUND: Thiazolidine-2,4-dione ring system is used as a pharmacophore to build various heterocyclic compounds aimed to interact with biological targets. In the present study, benzylidene-2,4-thiazolidinedione derivatives (compounds 2-5) were synt...
Evaluation of genotoxicity after acute and chronic exposure to 2,4-dichlorophenoxyacetic acid herbicide (2,4-D) in rodents using machine learning algorithms.
The Journal of toxicological sciences
Jan 1, 2020
2,4-Dichlorophenoxyacetic acid (2,4-D) is one of the most widely used herbicides in the world, but its mutagenic and carcinogenic potential is still controversial. We simulated environmental exposure to 2,4-D, with the objective of evaluating the gen...
A Framework for Automatic Recognition of Cell Damage on Microscopic Images using Artificial Neural Networks.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2018
Despite several technological advances in the past years, the vast majority of microscopy examinations continue to be performed in a very laborious, time-consuming manner, requiring highly experienced personnel to spend several hours to visually exam...
Genotoxicity in lead treated human lymphocytes evaluated by micronucleus and comet assays.
Indian journal of experimental biology
Aug 1, 2016
Lead (Pb) which plays a significant role in modern industry is related to a broad range of physiological, biochemical, behavioural and genetical dysfunctions. Its exposure leads to an increased frequency of genetic aberrations in humans. Hence, this ...
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