A multicentre verification study of the QuantiFERON-TB Gold Plus assay.

Journal: Tuberculosis (Edinburgh, Scotland)
PMID: 29523314

Abstract

OBJECTIVES: The aim of this verification study was to compare the QuantiFERON-TB Gold Plus (QFT-Plus) to the QuantiFERON-TB Gold In Tube (QFT-GIT). The new QFT-Plus test contains an extra antigen tube which, according to the manufacturer additionally elicits a CD8 T-cell response above the CD4 T-cell response. We assessed the value of this tube in detecting recent latent tuberculosis infections.

Authors

  • E D Pieterman
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands. Electronic address: e.pieterman@erasmusmc.nl.
  • F G Liqui Lung
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands.
  • A Verbon
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands; Department of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands.
  • H I Bax
    Department of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands.
  • C W Ang
    Department of Medical Microbiology and Infection Control, VU Medical Centre, Amsterdam, The Netherlands.
  • J Berkhout
    Department of Medical Microbiology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
  • G Blaauw
    Department of Medical Microbiology, Gelre Hospital, Apeldoorn, The Netherlands.
  • A Brandenburg
    Izore Centre for Infectious Diseases Friesland, Leeuwarden, The Netherlands.
  • N D van Burgel
    Department of Medical Microbiology, HAGA Hospital, Den Haag, The Netherlands.
  • A Claessen
    Department of Medical Microbiology and Immunology, St. Antonius Hospital, Nieuwegein, The Netherlands.
  • K van Dijk
    Department of Medical Microbiology and Infection Control, VU Medical Centre, Amsterdam, The Netherlands.
  • M Heron
    Department of Medical Microbiology and Immunology, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands.
  • M Hooghiemstra
    Izore Centre for Infectious Diseases Friesland, Leeuwarden, The Netherlands.
  • R Leussenkamp-Hummelink
    Labmicta, Hengelo, The Netherlands.
  • E van Lochem
    Department of Medical Microbiology and Immunology, Rijnstate Hospital, Arnhem, The Netherlands; Department of Clinical Chemistry, Gelderse Vallei Hospital, Ede, The Netherlands.
  • I H M van Loo
    Department of Medical Microbiology, Maastricht University Medical Centre, Maastricht, The Netherlands.
  • B Mulder
    Labmicta, Hengelo, The Netherlands.
  • A Ott
    Department of Medical Microbiology, Certe, Groningen, The Netherlands.
  • O Pontesilli
    Department of Medical Microbiology, Maasstad Hospital, Rotterdam, The Netherlands.
  • A Reuwer
    Department of Medical Microbiology and Immunology, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands.
  • P Rombouts
    Department of Medical Microbiology and Infectious Diseases, Ikazia Hospital, Rotterdam, The Netherlands.
  • V Saegeman
    Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium; Department of Microbiology and Immunology, K.U. Leuven, Leuven, Belgium.
  • M Scholing
    Department of Medical Microbiology, OLVG, Amsterdam, The Netherlands; Public Health Laboratory, Amsterdam, The Netherlands.
  • S Vainio
    Department of Medical Microbiology and Immunology, St. Antonius Hospital, Nieuwegein, The Netherlands.
  • J E M de Steenwinkel
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands.

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