AIMC Topic: Latent Tuberculosis

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Exploring T-cell metabolism in tuberculosis: development of a diagnostic model using metabolic genes.

European journal of medical research Jun 16, 2025
OBJECTIVES: The early diagnosis and immunoregulatory mechanisms of active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remain unclear, and the role of metabolic genes in host-pathogen interactions requires further investigation.
Humans Machine Learning Middle Aged Female Gene Expression Profiling Adult Tuberculosis T-Lymphocytes Latent Tuberculosis Male
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Rapid diagnosis of latent and active pulmonary tuberculosis by autofluorescence spectroscopy of blood plasma combined with artificial neural network algorithm.

Photodiagnosis and photodynamic therapy Nov 28, 2024
The existing clinical diagnostic methods of pulmonary tuberculosis (TB) usually have some of the following limitations, such as time-consuming, invasive, radioactive, insufficiently sensitive and accurate. This study demonstrates the possibility of u...
Tuberculosis, Pulmonary Latent Tuberculosis Humans Male Middle Aged Neural Networks, Computer Spectrometry, Fluorescence Algorithms Female Adult
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Identification of and as novel diagnostic biomarkers for latent tuberculosis infection using machine learning strategies and experimental verification.

Annals of medicine Jul 25, 2024
BACKGROUND: Current diagnostic methods cannot effectively distinguish between latent tuberculosis infection (LTBI) and active tuberculosis (ATB). This study aims to explore novel non-invasive diagnostic biomarkers for LTBI and to elucidate possible m...
ROC Curve Female Latent Tuberculosis Adult Male Humans Gene Expression Profiling Machine Learning Biomarkers
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Identification and validation of a pyroptosis-related signature in identifying active tuberculosis via a deep learning algorithm.

Frontiers in cellular and infection microbiology Nov 1, 2023
INTRODUCTION: Active tuberculosis (ATB), instigated by Mycobacterium tuberculosis (M.tb), rises as a primary instigator of morbidity and mortality within the realm of infectious illnesses. A significant portion of M.tb infections maintain an asymptom...
Deep Learning Pyroptosis Tuberculosis Latent Tuberculosis Humans Algorithms
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Risk assessment of latent tuberculosis infection through a multiplexed cytokine biosensor assay and machine learning feature selection.

Scientific reports Oct 15, 2021
Accurate detection and risk stratification of latent tuberculosis infection (LTBI) remains a major clinical and public health problem. We hypothesize that multiparameter strategies that probe immune responses to Mycobacterium tuberculosis can provide...
Middle Aged Risk Assessment Leukocytes, Mononuclear Biosensing Techniques Aged Adult Male Latent Tuberculosis Humans Machine Learning Cells, Cultured Cytokines Female
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ATBdiscrimination: An in Silico Tool for Identification of Active Tuberculosis Disease Based on Routine Blood Test and T-SPOT.TB Detection Results.

Journal of chemical information and modeling Oct 25, 2019
Tuberculosis remains one of the deadliest infectious diseases worldwide. Only 5-15% of people infected with develop active TB disease (ATB), while others remain latently infected (LTBI) during their lifetime, which has a completely different clinica...
Latent Tuberculosis Hematologic Tests Software Computer Simulation Tuberculosis Mycobacterium tuberculosis Humans Machine Learning
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A multicentre verification study of the QuantiFERON-TB Gold Plus assay.

Tuberculosis (Edinburgh, Scotland) Nov 28, 2017
OBJECTIVES: The aim of this verification study was to compare the QuantiFERON-TB Gold Plus (QFT-Plus) to the QuantiFERON-TB Gold In Tube (QFT-GIT). The new QFT-Plus test contains an extra antigen tube which, according to the manufacturer additionally...
Reproducibility of Results Adult Male Middle Aged Humans CD8-Positive T-Lymphocytes Mycobacterium tuberculosis Interferon-gamma Release Tests Female Predictive Value of Tests Netherlands Latent Tuberculosis CD4-Positive T-Lymphocytes Host-Pathogen Interactions Belgium Interferon-gamma Antigens, Bacterial
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Precision immunoprofiling to reveal diagnostic signatures for latent tuberculosis infection and reactivation risk stratification.

Integrative biology : quantitative biosciences from nano to macro Jan 1, 2019
Latent tuberculosis infection (LTBI) is estimated in nearly one quarter of the world's population, and of those immunocompetent and infected ~10% will proceed to active tuberculosis (TB). Current diagnostics cannot definitively identify LTBI and prov...
Photons Cytokines Prospective Studies Biomarkers Female Mycobacterium tuberculosis Aged Adult Diagnostic Tests, Routine Male Silicon Humans Latent Tuberculosis Machine Learning Tuberculin Test Computational Biology Algorithms Middle Aged Immune System Mass Screening Antigens Risk Assessment Immunoassay Leukocytes, Mononuclear Workflow
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Prevalence of latent Mycobacterium tuberculosis infection in renal transplant recipients.

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia Jan 1, 2018
OBJECTIVE: To estimate the prevalence of latent Mycobacterium tuberculosis infection (LTBI) in renal transplant recipients and to assess sociodemographic, behavioral, and clinical associations with positive tuberculin skin test (TST) results.
Tuberculin Test Male Prevalence Middle Aged Humans Aged Brazil Kidney Transplantation Young Adult Socioeconomic Factors Female Adult Multivariate Analysis Cross-Sectional Studies Latent Tuberculosis
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