BACKGROUND: The World Health Organization encourages the development of novel diagnostic tools based on 'non-sputum' samples to meet global goals for tuberculosis (TB) control. We aimed to develop a machine learning-driven model for TB diagnosis, usi...
BACKGROUND: Reactivation of latent tuberculosis infection (LTBI) is a major obstacle to tuberculosis eradication. Predicting LTBI relapse is crucial for effective disease management but remains underexplored.
The diagnosis of asymptomatic tuberculosis (TB) remains challenging due to an early disease stage. This study aimed to identify and validate plasma biomarkers for asymptomatic TB by integrating the Olink proteomics with multiple machine learning algo...
OBJECTIVES: The early diagnosis and immunoregulatory mechanisms of active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remain unclear, and the role of metabolic genes in host-pathogen interactions requires further investigation.
Photodiagnosis and photodynamic therapy
Nov 28, 2024
The existing clinical diagnostic methods of pulmonary tuberculosis (TB) usually have some of the following limitations, such as time-consuming, invasive, radioactive, insufficiently sensitive and accurate. This study demonstrates the possibility of u...
BACKGROUND: Current diagnostic methods cannot effectively distinguish between latent tuberculosis infection (LTBI) and active tuberculosis (ATB). This study aims to explore novel non-invasive diagnostic biomarkers for LTBI and to elucidate possible m...
Frontiers in cellular and infection microbiology
Nov 1, 2023
INTRODUCTION: Active tuberculosis (ATB), instigated by Mycobacterium tuberculosis (M.tb), rises as a primary instigator of morbidity and mortality within the realm of infectious illnesses. A significant portion of M.tb infections maintain an asymptom...
Accurate detection and risk stratification of latent tuberculosis infection (LTBI) remains a major clinical and public health problem. We hypothesize that multiparameter strategies that probe immune responses to Mycobacterium tuberculosis can provide...
Journal of chemical information and modeling
Oct 25, 2019
Tuberculosis remains one of the deadliest infectious diseases worldwide. Only 5-15% of people infected with develop active TB disease (ATB), while others remain latently infected (LTBI) during their lifetime, which has a completely different clinica...
OBJECTIVES: The aim of this verification study was to compare the QuantiFERON-TB Gold Plus (QFT-Plus) to the QuantiFERON-TB Gold In Tube (QFT-GIT). The new QFT-Plus test contains an extra antigen tube which, according to the manufacturer additionally...
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