Beam mask and sliding window-facilitated deep learning-based accurate and efficient dose prediction for pencil beam scanning proton therapy.

Journal: Medical physics
Published Date: Sep 25, 2023

Abstract

BACKGROUND: Accurate and efficient dose calculation is essential for on-line adaptive planning in proton therapy. Deep learning (DL) has shown promising dose prediction results in photon therapy. However, there is a scarcity of DL-based dose prediction methods specifically designed for proton therapy. Successful dose prediction method for proton therapy should account for more challenging dose prediction problems in pencil beam scanning proton therapy (PBSPT) due to its sensitivity to heterogeneities.

Authors

  • Lian Zhang
    Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA.
  • Jason M Holmes
    Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona, USA.
  • Zhengliang Liu
    School of Computing, University of Georgia, Athens, GA, United States.
  • Sujay A Vora
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, USA.
  • Terence T Sio
    Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona, USA.
  • Carlos E Vargas
    Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona.
  • Nathan Y Yu
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Sameer R Keole
    Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona.
  • Steven E Schild
    Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona.
  • Martin Bues
    Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona, USA.
  • Sheng Li
    School of Data Science, University of Virginia, Charlottesville, VA, United States.
  • Tianming Liu
    School of Computing, University of Georgia, Athens, GA, United States.
  • Jiajian Shen
    Department of Radiation Oncology, Mayo Clinic in Arizona, Phoenix, Arizona.
  • William W Wong
    Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona.
  • Wei Liu
    Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, United States.

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