Ct-based subregional radiomics using hand-crafted and deep learning features for prediction of therapeutic response to anti-PD1 therapy in NSCLC.

Journal: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
Published Date:

Abstract

PURPOSE: To develop and externally validate subregional radiomics for predicting therapeutic response to anti-PD1 therapy in non-small-cell lung cancer (NSCLC).

Authors

  • Yue Hu
    Department of Biobank, China-Japan Union Hospital of Jilin University, Changchun, China.
  • Tao Jiang
    Department of Respiratory and Critical Care Medicine, Center for Respiratory Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
  • Huan Wang
    Key Laboratory of Adaptation and Evolution of Plateau Biota (AEPB), Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Qinghai, P. R. China.
  • Jiangdian Song
    Sino-Dutch Biomedical and Information Engineering School, Northeastern University, Liaoning, Shenyang, 110819, China.
  • Zhiguang Yang
    Department of Radiology, Shengjing Hospital, Shenyang 110004, PR China.
  • Yan Wang
    College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
  • Juan Su
    Department of Dermatology, Xiangya Hospital Central South University, Changsha, China.
  • Meiqi Jin
    School of Intelligent Medicine, China Medical University, Liaoning, 110122, PR China.
  • Shijie Chang
    Department of Biomedical Engineering, China Medical University, Shenyang, 110122.
  • Kexue Deng
    Department of Radiology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine, USTC, Hefei, 230036, Anhui, China.
  • Wenyan Jiang
    Department of Intensive Care Unit, Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.