Characterizing mitochondrial features in osteoarthritis through integrative multi-omics and machine learning analysis.

Journal: Frontiers in immunology
PMID: 39026663

Abstract

PURPOSE: Osteoarthritis (OA) stands as the most prevalent joint disorder. Mitochondrial dysfunction has been linked to the pathogenesis of OA. The main goal of this study is to uncover the pivotal role of mitochondria in the mechanisms driving OA development.

Authors

  • Yinteng Wu
    Department of Orthopedic and Trauma Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Haifeng Hu
    School of Telecommunication and Information Engineering, Nanjing University of Posts and Telecommunications, Nanjing, China.
  • Tao Wang
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wenliang Guo
    Department of Rehabilitation Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Shijian Zhao
    Department of Cardiology, the Affiliated Cardiovascular Hospital of Kunming Medical University (Fuwai Yunnan Cardiovascular Hospital), Kunming, China.
  • Ruqiong Wei
    Department of Rehabilitation Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, China.

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