Enhancing a deep learning model for pulmonary nodule malignancy risk estimation in chest CT with uncertainty estimation.

Journal: European radiology
Published Date:

Abstract

OBJECTIVE: To investigate the effect of uncertainty estimation on the performance of a Deep Learning (DL) algorithm for estimating malignancy risk of pulmonary nodules.

Authors

  • Dré Peeters
    Diagnostic Imaging Analysis Group, Medical Imaging Department, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands. dre.peeters@radboudumc.nl.
  • Natália Alves
    Diagnostic Imaging Analysis Group, Medical Imaging Department, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands.
  • Kiran V Venkadesh
    Diagnostic Imaging Analysis Group, Medical Imaging Department, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands.
  • Renate Dinnessen
    Diagnostic Imaging Analysis Group, Medical Imaging Department, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands.
  • Zaigham Saghir
  • Ernst T Scholten
    From the Diagnostic Image Analysis Group, Radboud University Medical Center, Geert Groteplein 10, Nijmegen 6500 HB, the Netherlands (K.M., E.T.S., S.S., C.M.S., B.v.G.); Department of Radiology, Bernhoven Hospital, Uden, the Netherlands (H.S.); Department of Radiology, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands (A.J.G.K., M.B.J.M.K., T.S., M.R.); Department of Radiology, Meander Medisch Centrum, Amersfoort, the Netherlands (C.M.S.); and Thirona, Nijmegen, the Netherlands (R.H.H.M.P., A.M., J.M.).
  • Cornelia Schaefer-Prokop
    Diagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Rozemarijn Vliegenthart
    University of Groningen, University Medical Center Groningen, Department of Radiology, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
  • Mathias Prokop
    Department of Radiology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Colin Jacobs
    Diagnostic Image Analysis Group, Radboud University Medical Center, Nijmegen, The Netherlands.