Moderate, Short-Term, Local Hyperglycemia Attenuates Forearm Endothelium-Dependent Vasodilation After Transient Ischemia-Reperfusion in Human Volunteers.

Journal: Journal of cardiothoracic and vascular anesthesia
PMID: 28284926

Abstract

OBJECTIVE: Acute hyperglycemia causes endothelial dysfunction in diabetic patients, abolishes ischemic pre- and postconditioning, and is an independent predictor of adverse outcome after myocardial infarction in nondiabetic patients. Its effects on endothelial-dependent vasodilation are controversial in healthy subjects. The authors studied the effect of moderate short-term local hyperglycemia on forearm endothelium-dependent vasodilation in healthy volunteers.

Authors

  • Thomas J Ebert
    Anesthesia Service, the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI. Electronic address: tjebert@mcw.edu.
  • Jutta Novalija
    Anesthesia Service, the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI.
  • Jill A Barney
    Anesthesia Service, the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI.
  • Toni D Uhrich
    Anesthesia Service, the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI.
  • Shahbaz R Arain
    Anesthesia Service, the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI.
  • Julie K Freed
    Anesthesia Service, the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI.
  • Paul S Pagel
    Anesthesia Service, the Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI.

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