AIMC Topic: Vasodilation

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Artificial intelligence-driven identification of morin analogues acting as Ca1.2 channel blockers: Synthesis and biological evaluation.

Bioorganic chemistry Dec 17, 2022
Morin is a vasorelaxant flavonoid, whose activity is ascribable to Ca1.2 channel blockade that, however, is weak as compared to that of clinically used therapeutic agents. A conventional strategy to circumvent this drawback is to synthesize new deriv...
Vasodilation Calcium Channel Blockers Vasodilator Agents Artificial Intelligence Calcium Channels, L-Type Animals Rats Flavonoids
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Vascular Aging Detected by Peripheral Endothelial Dysfunction Is Associated With ECG-Derived Physiological Aging.

Journal of the American Heart Association Jan 17, 2021
Background An artificial intelligence algorithm that detects age using the 12-lead ECG has been suggested to signal "physiologic age." This study aimed to investigate the association of peripheral microvascular endothelial function (PMEF) as an index...
Male Aging Middle Aged Electrocardiography Female Risk Factors Cross-Sectional Studies Arteries Microvessels Follow-Up Studies Peripheral Arterial Disease Vasodilation Endothelium, Vascular Humans Artificial Intelligence Retrospective Studies
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Detecting Vasodilation as Potential Diagnostic Biomarker in Breast Cancer Using Deep Learning-Driven Thermomics.

Biosensors Oct 31, 2020
Breast cancer is the most common cancer in women. Early diagnosis improves outcome and survival, which is the cornerstone of breast cancer treatment. Thermography has been utilized as a complementary diagnostic technique in breast cancer detection. A...
Early Detection of Cancer Mammography Vasodilation Thermography Biomarkers Female Breast Neoplasms Deep Learning Humans Artificial Intelligence
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Moderate, Short-Term, Local Hyperglycemia Attenuates Forearm Endothelium-Dependent Vasodilation After Transient Ischemia-Reperfusion in Human Volunteers.

Journal of cardiothoracic and vascular anesthesia Dec 2, 2016
OBJECTIVE: Acute hyperglycemia causes endothelial dysfunction in diabetic patients, abolishes ischemic pre- and postconditioning, and is an independent predictor of adverse outcome after myocardial infarction in nondiabetic patients. Its effects on e...
Hyperglycemia Reperfusion Injury Acute Disease Double-Blind Method Single-Blind Method Glucose Regional Blood Flow Young Adult Adult Male Pilot Projects Humans Endothelium, Vascular Female Forearm Infusions, Intra-Arterial Vasodilation Cross-Over Studies Healthy Volunteers
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Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning.

Cardiovascular research Jan 29, 2022
AIMS: Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine lea...
Humans Machine Learning Photic Stimulation Retinal Vessels Arterioles Venules Light Vasodilation Heart Disease Risk Factors Treatment Outcome Cluster Analysis Predictive Value of Tests Cardiovascular Diseases Kidney Failure, Chronic Female Middle Aged Cause of Death Aged Risk Assessment Signal Processing, Computer-Assisted Male Renal Dialysis Workflow
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Antihypertensive Activity of Sauromatum guttatum Mediated by Vasorelaxation and Myocardial Depressant Effects.

Arquivos brasileiros de cardiologia Dec 1, 2021
BACKGROUND: Sauromatum guttatum (S. guttatum) is used in the treatment of blood disorders and reportedly has a spasmolytic activity through Ca2+ channel inhibition.
Antihypertensive Agents Calcium Atropine Derivatives Humans Rats Receptors, Muscarinic Anti-Arrhythmia Agents Animals Vasodilation Hypertension Plant Extracts Verapamil Rats, Sprague-Dawley Blood Pressure
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Ex-vivo antihypertensive and calcium channel blocking activity of Androsace foliosa n-hexane leaves fraction on isolated rabbit aorta.

Pakistan journal of pharmaceutical sciences Nov 1, 2019
Hypertension is persistent elevation in blood pressure for 3-4 weeks. Estimated global prevalence of hypertension suggested that by the Year 2025 (29%) of adult worldwide are suffering from hypertension (1.56 billion). Hypertension complications are ...
Primulaceae Plant Extracts Aorta, Thoracic Hypertension Calcium Channel Blockers Antihypertensive Agents Female Plant Leaves Calcium Channels Rabbits Blood Pressure Hexanes Animals Vasodilation In Vitro Techniques
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Extracted Anaxagorea luzonensis A. Gray Restored Impairment of Endothelium-Dependent Vasorelaxation Induced by Homocysteine Thiolactone in Rat Aortic Rings.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet Nov 1, 2015
OBJECTIVE: To investigate the beneficial effects of Anaxagorea luzonensis (AL) extract on homocysteine thiolactone (HTL)-induced impairment of endothelium-dependent relaxation in rat aortic rings. The mechanisms involved in the effects of AL on endot...
Male Annonaceae Vasodilation Animals Plant Extracts Homocysteine Rats, Wistar Aorta, Thoracic Rats Endothelium, Vascular
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