Machine-learning-based plasma metabolomic profiles for predicting long-term complications of cirrhosis.

Journal: Hepatology (Baltimore, Md.)
Published Date: Apr 17, 2024

Abstract

BACKGROUND AND AIMS: The complications of liver cirrhosis occur after long asymptomatic stages of progressive fibrosis and are generally diagnosed late. We aimed to develop a plasma metabolomic-based score tool to predict these events.

Authors

  • Chengnan Guo
    Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, China.
  • Zhenqiu Liu
    1 Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center , Los Angeles, California.
  • Hong Fan
    Glorious Sun School of Business and Management, Donghua University, Shanghai 200051, People's Republic of China.
  • Haili Wang
    Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety (Fudan University), Ministry of Education, Fudan University, Shanghai, China.
  • Xin Zhang
    First Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Shuzhen Zhao
    Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety (Fudan University), Ministry of Education, Fudan University, Shanghai, China.
  • Yi Li
    Wuhan Zoncare Bio-Medical Electronics Co., Ltd, Wuhan, China.
  • Xinyu Han
    Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety (Fudan University), Ministry of Education, Fudan University, Shanghai, China.
  • Tianye Wang
    Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety (Fudan University), Ministry of Education, Fudan University, Shanghai, China.
  • Xingdong Chen
    State Key Laboratory of Genetic Engineering, Human Phenome Institute, and School of Life Sciences, Fudan University, Shanghai, China.
  • Tiejun Zhang
    Key Laboratory of Public Health Safety, Fudan University, Ministry of Education, Shanghai, China.

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