Validated machine learning tools to distinguish immune checkpoint inhibitor, radiotherapy, COVID-19 and other infective pneumonitis.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
PMID: 38582181

Abstract

BACKGROUND: Pneumonitis is a well-described, potentially disabling, or fatal adverse effect associated with both immune checkpoint inhibitors (ICI) and thoracic radiotherapy. Accurate differentiation between checkpoint inhibitor pneumonitis (CIP) radiation pneumonitis (RP), and infective pneumonitis (IP) is crucial for swift, appropriate, and tailored management to achieve optimal patient outcomes. However, correct diagnosis is often challenging, owing to overlapping clinical presentations and radiological patterns.

Authors

  • Sumeet Hindocha
    Division of Radiotherapy and Imaging, the Institute of Cancer, London, SM2 5NG, UK.
  • Benjamin Hunter
    Cancer Imaging Centre, Department of Surgery & Cancer, Imperial College London, Du Cane Road, London, W12 0NN, UK.
  • Kristofer Linton-Reid
    Cancer Imaging Centre, Department of Surgery & Cancer, Imperial College London, Du Cane Road, London W12 0NN, UK.
  • Thomas George Charlton
    Guy's Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE19RT, UK.
  • Mitchell Chen
    Department of Surgery and Cancer, The Commonwealth Building, Du Cane Road, Hammersmith Campus, Imperial College, London W12 0NN, UK; Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK.
  • Andrew Logan
    Department of Surgery and Cancer, Imperial College London, Du Cane Road, London W12 0NN, UK.
  • Merina Ahmed
    Lung Unit, The Royal Marsden NHS Foundation Trust, Sutton, SM2 5PT, UK.
  • Imogen Locke
    Lung Unit, The Royal Marsden NHS Foundation Trust, Downs Road, Sutton SM25PT, UK.
  • Bhupinder Sharma
    Division of Radiotherapy and Imaging, the Institute of Cancer, London, SM2 5NG, UK.
  • Simon Doran
    Institute of Cancer Research, London, UK.
  • Matthew Orton
    Artificial Intelligence Imaging Hub, Royal Marsden NHS Foundation Trust, Downs Road, Sutton SM25PT, UK.
  • Catey Bunce
    Institute of Cancer Research NIHR Biomedical Research Centre, London, UK.
  • Danielle Power
    Department of Clinical Oncology, Imperial College Healthcare NHS Trust, Fulham Palace Road, London W6 8RF, UK.
  • Shahreen Ahmad
    Guy's Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE19RT, UK.
  • Karen Chan
    Guy's Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE19RT, UK.
  • Peng Ng
    Guy's Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE19RT, UK.
  • Richard Toshner
    Interstitial lung disease unit, St Bartholomews' Hospital, Barts Health NHS Trust, West Smithfield, London EC1A 7BE, UK.
  • Binnaz Yasar
    Department of Clinical Oncology, St Batholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, EC1A 7BE, UK.
  • John Conibear
    Department of Clinical Oncology, St Batholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, EC1A 7BE, UK.
  • Ravindhi Murphy
    Chelsea and Westminster Hospital, Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London SW10 9NH, UK.
  • Tom Newsom-Davis
    Chelsea and Westminster Hospital, Chelsea and Westminster NHS Foundation Trust, 369 Fulham Road, London SW10 9NH, UK.
  • Patrick Goodley
    Lung Cancer & Thoracic Surgery Directorate, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Greater Manchester, UK; Division of Immunology, Immunity to Infection & Respiratory Medicine, University of Manchester, Manchester, UK.
  • Matthew Evison
    Department of Respiratory Medicine, University Hospital of South Manchester, Manchester, UK.
  • Nadia Yousaf
    Lung Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London SW36JJ, UK.
  • George Bitar
    Department of Radiology, The Royal Marsden NHS Foundation Trust, Fulham Road, London SW36JJ, UK.
  • Fiona McDonald
    Lung Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London SW36JJ, UK.
  • Matthew Blackledge
    Radiotherapy and Imaging, Institute of Cancer Research, 123 Old Brompton Road, London SW7 3RP, UK.
  • Eric Aboagye
    Department of Cancer and Surgery, Imperial College London, London, UK.
  • Richard Lee

Keywords

External Resources

Popular Topics
Recent Journals