Role of Antioxidants in Horse Serum-mediated Vasculitis in Swine: Potential Relevance to Early Treatment in Mitigation of Coronary Arteritis in Kawasaki Disease.

Journal: Pediatrics and neonatology
PMID: 28209472

Abstract

BACKGROUND: Horse serum-induced immune complex coronary vasculitis in swine is the first experimental model to mimic most of the pictures of Kawasaki disease. Immune complex mechanism has been implicated as one of the possible mechanisms in the pathogenesis of vasculitis in Kawasaki disease. Antioxidants have a significant role in the reduction of cardiovascular diseases in both human and animal studies. We tried giving vitamins A, E, and C to treat immune complex vasculitis, in the hope of mitigating coronary vasculitis in Kawasaki disease.

Authors

  • Saji Philip
    Department of Pediatric Cardiology, St. Gregorios Cardio-Vascular Center, Parumala, Kerala, India; Division of Biotechnology, Cardiovascular Research Centre, Animal Technology Institute, Miaoli, Taiwan. Electronic address: tfcsaji@yahoo.co.in.
  • Wen-Chuan Lee
    Division of Biotechnology, Cardiovascular Research Centre, Animal Technology Institute, Miaoli, Taiwan.
  • Kotturathu Mammen Cherian
    Department of Pediatric Cardiology, St. Gregorios Cardio-Vascular Center, Parumala, Kerala, India; Department of Cardiothoracic Surgery, Frontier Lifeline Hospital, Dr. K. M. Cherian Heart Foundation, Chennai, India.
  • Mei-Hwan Wu
    Division of Pediatric Cardiology, Department of Pediatrics, National Taiwan University Children's Hospital, National Taiwan University, Taipei, Taiwan.
  • Hung-Chi Lue
    Division of Pediatric Cardiology, Department of Pediatrics, National Taiwan University Children's Hospital, National Taiwan University, Taipei, Taiwan.

Keywords

External Resources

Popular Topics
Recent Journals