Appropriate use of blood cultures in the emergency department through machine learning (ABC): study protocol for a randomised controlled non-inferiority trial.

Journal: BMJ open
PMID: 38821574

Abstract

INTRODUCTION: The liberal use of blood cultures in emergency departments (EDs) leads to low yields and high numbers of false-positive results. False-positive, contaminated cultures are associated with prolonged hospital stays, increased antibiotic usage and even higher hospital mortality rates. This trial aims to investigate whether a recently developed and validated machine learning model for predicting blood culture outcomes can safely and effectively guide clinicians in withholding unnecessary blood culture analysis.

Authors

  • Anuschka Y van der Zaag
    Department of Internal Medicine, Division of Acute Medicine, Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands.
  • Sheena C Bhagirath
    Department of Internal Medicine, Division of Acute Medicine, Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands.
  • Anneroos W Boerman
    Department of Internal Medicine, Section General Internal Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
  • Michiel Schinkel
  • Ketan Paranjape
  • Kaoutar Azijli
    Department of Emergency Medicine, Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands.
  • Milan L Ridderikhof
    Department of Emergency Medicine, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands.
  • Mei Lie
    Department of EVA Service Center, Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands.
  • Birgit Lissenberg-Witte
    Department of Epidemiology & Data Science, Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands.
  • Rogier Schade
    Department of Medical Microbiology and Infection Prevention, Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands.
  • Joost Wiersinga
    Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC Locatie AMC, Amsterdam, The Netherlands.
  • Robert de Jonge
    Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit & University of Amsterdam, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands. Electronic address: r.dejonge1@amsterdamumc.nl.
  • Prabath W B Nanayakkara
    Department of Internal Medicine, Section General Internal Medicine, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.

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