AIMC Topic: Blood Culture

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Development and evaluation of a direct disk diffusion, rapid antimicrobial susceptibility testing method from blood culture positive for Gram-negative bacilli using rapid molecular testing and microbiology laboratory automation.

Microbiology spectrum May 15, 2025
Rapid antimicrobial susceptibility testing (RAST) using disk diffusion (DD) from positive blood cultures (BC) can aid initiation of effective antimicrobial therapy. Rapid molecular blood culture identification panels (BCID) and microbiology laborator...
Humans Automation, Laboratory Anti-Bacterial Agents Pseudomonas aeruginosa Disk Diffusion Antimicrobial Tests Gram-Negative Bacteria Gram-Negative Bacterial Infections Microbial Sensitivity Tests Klebsiella pneumoniae Blood Culture Escherichia coli
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High procalcitonin level is related to blood stream infections, gram-negative pathogens, and ICU admission in infections of adult febrile cancer patients.

Journal of the Egyptian National Cancer Institute May 10, 2025
BACKGROUND: Blood stream infection (BSI) represent a life-threatening condition. Thus, we aimed to investigate the role of procalcitonin (PCT) and C-reactive protein (CRP) tests in adult febrile patients with BSI and other clinical infections in hosp...
Biomarkers Fever Bacteremia Intensive Care Units Gram-Negative Bacteria Humans Female Blood Culture Gram-Negative Bacterial Infections Adult Procalcitonin Aged Male C-Reactive Protein Middle Aged Neoplasms
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AI Enhanced explainable early prediction of blood culture positivity in neutropenic patients using clinical and hematologic parameters.

Computers in biology and medicine Mar 15, 2025
Leukemia patients who receive chemotherapy experience a decline in neutrophils and an increased risk of infections. Neutropenic sepsis is a life-threatening condition and a major cause of cancer-related mortality. Patients with neutropenic sepsis are...
Neutropenia Humans Machine Learning Sepsis Female Bacteremia Aged Blood Culture Adult Male Middle Aged
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Rapid detection of carbapenem-resistant Escherichia coli and carbapenem-resistant Klebsiella pneumoniae in positive blood cultures via MALDI-TOF MS and tree-based machine learning models.

BMC microbiology Jan 24, 2025
BACKGROUND: Bloodstream infection (BSI) is a systemic infection that predisposes individuals to sepsis and multiple organ dysfunction syndrome. Early identification of infectious agents and determination of drug-resistant phenotypes can help patients...
Anti-Bacterial Agents Microbial Sensitivity Tests Klebsiella pneumoniae Bacteremia Humans Machine Learning Carbapenem-Resistant Enterobacteriaceae Decision Trees Escherichia coli Infections Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Carbapenems Blood Culture Klebsiella Infections Escherichia coli
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Clinical evaluation of a multiplex droplet digital PCR for diagnosing suspected bloodstream infections: a prospective study.

Frontiers in cellular and infection microbiology Jan 16, 2025
BACKGROUND: Though droplet digital PCR (ddPCR) has emerged as a promising tool for early pathogen detection in bloodstream infections (BSIs), more studies are needed to support its clinical application widely due to different ddPCR platforms with dis...
Molecular Diagnostic Techniques DNA, Bacterial Male Middle Aged Sepsis Aged Humans ROC Curve Multiplex Polymerase Chain Reaction Aged, 80 and over Bacteria Adult Prospective Studies Bacteremia Sensitivity and Specificity Female Blood Culture
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Utilizing deep learning-based causal inference to explore vancomycin's impact on continuous kidney replacement therapy necessity in blood culture-positive intensive care unit patients.

Microbiology spectrum Dec 10, 2024
Patients with positive blood cultures in the intensive care unit (ICU) are at high risk for septic acute kidney injury requiring continuous kidney replacement therapy (CKRT), especially when treated with vancomycin. This study developed a machine lea...
Male Middle Aged Deep Learning Sepsis Female Aged Adult Blood Culture Vancomycin Humans Machine Learning Anti-Bacterial Agents Retrospective Studies Continuous Renal Replacement Therapy Acute Kidney Injury Intensive Care Units
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Distinguishing neonatal culture-negative sepsis from rule-out sepsis with artificial intelligence-derived graphs.

Pediatric research Aug 15, 2024
Novel artificial intelligence methods can aide in identification of cases of conditions using only unstructured electronic health record data. This graph-based method compares comprehensive electronic health records among neonates using temporal data...
Neonatal Sepsis Female Infant, Newborn Sepsis Blood Culture Humans Artificial Intelligence Electronic Health Records
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Appropriate use of blood cultures in the emergency department through machine learning (ABC): study protocol for a randomised controlled non-inferiority trial.

BMJ open May 31, 2024
INTRODUCTION: The liberal use of blood cultures in emergency departments (EDs) leads to low yields and high numbers of false-positive results. False-positive, contaminated cultures are associated with prolonged hospital stays, increased antibiotic us...
Length of Stay Hospital Mortality Blood Culture Randomized Controlled Trials as Topic Emergency Service, Hospital Netherlands Unnecessary Procedures Humans Equivalence Trials as Topic Machine Learning Anti-Bacterial Agents
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Deep learning model for prediction of extended-spectrum beta-lactamase (ESBL) production in community-onset Enterobacteriaceae bacteraemia from a high ESBL prevalence multi-centre cohort.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology Jan 5, 2021
Adequate empirical antimicrobial coverage is instrumental in clinical management of community-onset Enterobacteriaceae bacteraemia in areas with high ESBL prevalence, while balancing the risk of carbapenem overuse and emergence of carbapenem-resistan...
Humans Deep Learning Cohort Studies Blood Culture Models, Biological beta-Lactamases Enterobacteriaceae Community-Acquired Infections Hong Kong Multivariate Analysis Enterobacteriaceae Infections
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Assessment of version 2.5 of QMAC-dRAST for rapid antimicrobial susceptibility testing with reduced sample-to-answer turnaround time and an integrated expert system.

Infectious diseases now Dec 30, 2020
OBJECTIVE: To assess the performance of the new rapid antimicrobial susceptibility testing (AST) QMAC-dRAST V2.5 system.
Gram-Negative Bacteria Anti-Bacterial Agents Microbial Sensitivity Tests Blood Culture Expert Systems
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