3DVascNet: An Automated Software for Segmentation and Quantification of Mouse Vascular Networks in 3D.
Journal:
Arteriosclerosis, thrombosis, and vascular biology
Published Date:
May 23, 2024
Abstract
BACKGROUND: Analysis of vascular networks is an essential step to unravel the mechanisms regulating the physiological and pathological organization of blood vessels. So far, most of the analyses are performed using 2-dimensional projections of 3-dimensional (3D) networks, a strategy that has several obvious shortcomings. For instance, it does not capture the true geometry of the vasculature and generates artifacts on vessel connectivity. These limitations are accepted in the field because manual analysis of 3D vascular networks is a laborious and complex process that is often prohibitive for large volumes.