Development of interpretable machine learning models to predict in-hospital prognosis of acute heart failure patients.

Journal: ESC heart failure
Published Date: May 15, 2024

Abstract

AIMS: In recent years, there has been remarkable development in machine learning (ML) models, showing a trend towards high prediction performance. ML models with high prediction performance often become structurally complex and are frequently perceived as black boxes, hindering intuitive interpretation of the prediction results. We aimed to develop ML models with high prediction performance, interpretability, and superior risk stratification to predict in-hospital mortality and worsening heart failure (WHF) in patients with acute heart failure (AHF).

Authors

  • Munekazu Tanaka
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Hirohiko Kohjitani
    Department of Biomedical Data Intelligence, Graduate School of Medicine, Kyoto University, Kyoto, Japan. kohjitani.hirohiko.7z@kyoto-u.ac.jp.
  • Erika Yamamoto
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Takeshi Morimoto
    Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan.
  • Takao Kato
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Hidenori Yaku
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Yasutaka Inuzuka
    Department of Cardiovascular Medicine, Shiga General Hospital, Moriyama, Japan.
  • Yodo Tamaki
    Division of Cardiology, Tenri Hospital, Tenri, Japan.
  • Neiko Ozasa
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Yuta Seko
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Masayuki Shiba
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Yusuke Yoshikawa
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Yugo Yamashita
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Takeshi Kitai
  • Ryoji Taniguchi
    Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.
  • Moritake Iguchi
    Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
  • Kazuya Nagao
    Department of Cardiology, Osaka Red Cross Hospital, Osaka, Japan.
  • Takafumi Kawai
    Department of Cardiology, Kishiwada City Hospital, Kishiwada, Japan.
  • Akihiro Komasa
    Department of Cardiology, Kansai Electric Power Hospital, Osaka, Japan.
  • Yuichi Kawase
    Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan.
  • Takashi Morinaga
    Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
  • Mamoru Toyofuku
    Department of Cardiology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
  • Yutaka Furukawa
    Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
  • Kenji Ando
    Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
  • Kazushige Kadota
    Department of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan.
  • Yukihito Sato
    Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan.
  • Koichiro Kuwahara
    Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
  • Yasushi Okuno
    Graduate School of Medicine, Kyoto University, Shogoin-kawaharacho, city/>Sakyo-ku Kyoto, 606-8507, Japan.
  • Takeshi Kimura
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
  • Koh Ono
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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