Microscope-integrated optical coherence tomography for in vivo human brain tumor detection with artificial intelligence.

Journal: Journal of neurosurgery
Published Date: May 3, 2024

Abstract

OBJECTIVE: It has been shown that optical coherence tomography (OCT) can identify brain tumor tissue and potentially be used for intraoperative margin diagnostics. However, there is limited evidence on its use in human in vivo settings, particularly in terms of its applicability and accuracy of residual brain tumor detection (RTD). For this reason, a microscope-integrated OCT system was examined to determine in vivo feasibility of RTD after resection with automated scan analysis.

Authors

  • Patrick Kuppler
    1Department of Neurosurgery, University Medical Center Schleswig-Holstein, Campus Luebeck.
  • Paul Strenge
    2Medical Laser Center Luebeck.
  • Birgit Lange
    2Medical Laser Center Luebeck.
  • Sonja Spahr-Hess
    1Department of Neurosurgery, University Medical Center Schleswig-Holstein, Campus Luebeck.
  • Wolfgang Draxinger
    3University of Luebeck, Institute of Biomedical Optics, Luebeck; and.
  • Christian Hagel
    4University Medical Center Hamburg-Eppendorf, Institute of Neuropathology, Hamburg, Germany.
  • Dirk Theisen-Kunde
    2Medical Laser Center Luebeck.
  • Ralf Brinkmann
    2Medical Laser Center Luebeck.
  • Robert Huber
    3University of Luebeck, Institute of Biomedical Optics, Luebeck; and.
  • Volker Tronnier
    1Department of Neurosurgery, University Medical Center Schleswig-Holstein, Campus Luebeck.
  • Matteo Mario Bonsanto
    Department of Neurosurgery, University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538, Lübeck, Germany.

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