Multi-omics deep learning for radiation pneumonitis prediction in lung cancer patients underwent volumetric modulated arc therapy.

Journal: Computer methods and programs in biomedicine
PMID:

Abstract

BACKGROUND AND OBJECTIVE: To evaluate the feasibility and accuracy of radiomics, dosiomics, and deep learning (DL) in predicting Radiation Pneumonitis (RP) in lung cancer patients underwent volumetric modulated arc therapy (VMAT) to improve radiotherapy safety and management.

Authors

  • Wanyu Su
    Department of Radiotherapy Center, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang 315000, China.
  • Dezhi Cheng
    Department of Thoracic Surgery, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
  • Weihua Ni
    Department of Radiotherapy Center, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang 315000, China.
  • Yao Ai
    Radiotherapy Center, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Xianwen Yu
    ByteDance Inc, Beijing, China.
  • Ninghang Tan
    Department of Radiotherapy Center, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang 315000, China.
  • Jianping Wu
    Department of Civil Engineering, Tsinghua University, Beijing, 100084, China.
  • Wen Fu
    Department of Radiotherapy Center, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
  • Chenyu Li
    Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology of Shaanxi Province, College of Life Sciences, Northwest University, Xi'an 710069, China.
  • Congying Xie
    Department of Radiation and Medical Oncology, The 1st Affiliated Hospital of Wenzhou Medical University, No.2 Fuxue Lane, Wenzhou, 325000, People's Republic of China. wzxiecongying@163.com.
  • Meixiao Shen
    Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China. Electronic address: smx77@mail.eye.ac.cn.
  • Xiance Jin
    Department of Radiation and Medical Oncology, The 1st Affiliated Hospital of Wenzhou Medical University, No.2 Fuxue Lane, Wenzhou, 325000, People's Republic of China.