Thrombomodulin as a potential diagnostic marker of acute myocardial infarction and correlation with immune infiltration: Comprehensive analysis based on multiple machine learning.

Journal: Transplant immunology
Published Date:

Abstract

BACKGROUND: Acute myocardial infarction (AMI) is a global health problem with high mortality. Early diagnosis can prevent the development of AMI and provide valuable information for subsequent treatment. Angiogenesis has been shown to be a critical factor in the development of infarction and targeting this process may be a potential protective strategy for preventing myocardial injury and improving the prognosis of AMI patients. This study aimed to screen and verify diagnostic markers related to angiogenesis in AMI and to investigate the molecular mechanisms of action associated with AMI in terms of immune cell infiltration.

Authors

  • Guoqing Liu
    Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning, Guangxi, China.
  • Lixia Huang
    Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Cardiovascular Institute, Nanning, Guangxi, China.
  • Xiangwen Lv
    Department of Cardiology, The Second Affiliated Hospital Guangxi Medical University, Nanning, Guangxi, China.
  • Yuting Guan
    Guangxi Medical University, Nanning, Guangxi, China.
  • Lang Li
    Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.