Identification of shared gene signatures and pathways for diagnosing osteoporosis with sarcopenia through integrated bioinformatics analysis and machine learning.

Journal: BMC musculoskeletal disorders
Published Date: Jun 3, 2024

Abstract

BACKGROUND: Prior studies have suggested a potential relationship between osteoporosis and sarcopenia, both of which can present symptoms of compromised mobility. Additionally, fractures among the elderly are often considered a common outcome of both conditions. There is a strong correlation between fractures in the elderly population, decreased muscle mass, weakened muscle strength, heightened risk of falls, and diminished bone density. This study aimed to pinpoint crucial diagnostic candidate genes for osteoporosis patients with concomitant sarcopenia.

Authors

  • Xiaoli Zhou
    Department of Traditional Chinese Medicine, College of Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
  • Lina Zhao
    College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, China.
  • Zepei Zhang
    Department of Spine Surgery, Tianjin Hospital, Tianjin University, Tianjin, 300211, China.
  • Yang Chen
    Orthopedics Department of the First Affiliated Hospital of Tsinghua University, Beijing, China.
  • Guangdong Chen
    Department of Orthopaedics, Cangzhou Central Hospital, Hebei, 061001, China.
  • Jun Miao
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106.
  • Xiaohui Li
    Department of Ophthalmology, Ningbo Yinzhou No.2 Hospital, Ningbo Urology and Nephrology Hospital, Ningbo, Zhejiang, China.

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