Identification of Multiclass Pediatric Low-Grade Neuroepithelial Tumor Molecular Subtype with ADC MR Imaging and Machine Learning.

Journal: AJNR. American journal of neuroradiology
Published Date:

Abstract

BACKGROUND AND PURPOSE: Molecular biomarker identification increasingly influences the treatment planning of pediatric low-grade neuroepithelial tumors (PLGNTs). We aimed to develop and validate a radiomics-based ADC signature predictive of the molecular status of PLGNTs.

Authors

  • Matheus D Soldatelli
    From the Department Diagnostic Imaging (M.D.S., B.B.E.-W., M.W.W.), Division of Neuroradiology, The Hospital for Sick Children, Toronto, Ontario, Canada md.soldatelli@gmail.com.
  • Khashayar Namdar
    Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.
  • Uri Tabori
    Institute of Medical Science (M.D.S., K.N., U.T., F.K., B.B.E.-W.), University of Toronto, Toronto, Ontario, Canada.
  • Cynthia Hawkins
    The Arthur and Sonia Labatt Brain Tumour Research Centre (U.T., C.H.), The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Kristen Yeom
    Department of Radiology (K.Y.), Lucile Packard Children's Hospital, Stanford University School of Medicine, Stanford, California.
  • Farzad Khalvati
    Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada. farzad.khalvati@utoronto.ca.
  • Birgit B Ertl-Wagner
    From the Department of Radiology, University of Wisconsin Madison School of Medicine and Public Health, 600 Highland Dr, Madison, WI 53792 (D.A.B., M.L.S.); Department of Radiology, New York University, New York, NY (L.M.); Department of Musculoskeletal Radiology (M.A.B.) and Institute for Technology Assessment (E.F.H.), Massachusetts General Hospital, Boston, Mass; Department of Medical Imaging, Hospital for Sick Children, University of Toronto, Toronto, Canada (B.B.E.W.); Department of Radiology, University of California-San Diego, San Diego, Calif (K.J.F.); Department of Cancer Imaging, Division of Imaging Sciences & Biomedical Engineering, Kings College London, London, England (V.J.G.); Department of Radiology and Biomedical Imaging, University of California-San Francisco, San Francisco, Calif (C.P.H.); and Department of Radiology and Radiologic Science, The Johns Hopkins University School of Medicine, Baltimore, Md (C.R.W.).
  • Matthias W Wagner
    Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.