AIMC Topic: Proto-Oncogene Proteins B-raf
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Can mutation abundance assess the biological behavior of BRAF-positive papillary thyroid carcinoma?
Journal of translational medicine
Jul 1, 2025
BACKGROUND: BRAF mutation is the most common genetic change in papillary thyroid carcinoma (PTC). Nevertheless, the association between BRAF mutation status and abundance and the biological behavior of PTC is unclear. Thus, this study investigated wh...
Performance of Machine Learning Models in Predicting BRAF Alterations Using Imaging Data in Low-Grade Glioma: A Systematic Review and Meta-Analysis.
World neurosurgery
Feb 25, 2025
BACKGROUND: Understanding the BRAF alterations preoperatively could remarkably assist in predicting tumor behavior, which leads to a more precise prognostication and management strategy. Recent advances in artificial intelligence (AI) have resulted i...
Breaking barriers: noninvasive AI model for BRAF mutation identification.
International journal of computer assisted radiology and surgery
Feb 15, 2025
OBJECTIVE: BRAF is the most common mutation found in thyroid cancer and is particularly associated with papillary thyroid carcinoma (PTC). Currently, genetic mutation detection relies on invasive procedures. This study aimed to extract radiomic featu...
Classifying driver mutations of papillary thyroid carcinoma on whole slide image: an automated workflow applying deep convolutional neural network.
Frontiers in endocrinology
Nov 6, 2024
BACKGROUND: Informative biomarkers play a vital role in guiding clinical decisions regarding management of cancers. We have previously demonstrated the potential of a deep convolutional neural network (CNN) for predicting cancer driver gene mutations...
Identification of Multiclass Pediatric Low-Grade Neuroepithelial Tumor Molecular Subtype with ADC MR Imaging and Machine Learning.
AJNR. American journal of neuroradiology
Jun 7, 2024
BACKGROUND AND PURPOSE: Molecular biomarker identification increasingly influences the treatment planning of pediatric low-grade neuroepithelial tumors (PLGNTs). We aimed to develop and validate a radiomics-based ADC signature predictive of the molec...
Deep neural network for the prediction of KRAS, NRAS, and BRAF genotypes in left-sided colorectal cancer based on histopathologic images.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
May 12, 2024
BACKGROUND: The KRAS, NRAS, and BRAF genotypes are critical for selecting targeted therapies for patients with metastatic colorectal cancer (mCRC). Here, we aimed to develop a deep learning model that utilizes pathologic whole-slide images (WSIs) to ...
Histological interpretation of spitzoid tumours: an extensive machine learning-based concordance analysis for improving decision making.
Histopathology
Apr 12, 2024
The histopathological classification of melanocytic tumours with spitzoid features remains a challenging task. We confront the complexities involved in the histological classification of these tumours by proposing machine learning (ML) algorithms tha...
Social network analysis of cell networks improves deep learning for prediction of molecular pathways and key mutations in colorectal cancer.
Medical image analysis
Jan 5, 2024
Colorectal cancer (CRC) is a primary global health concern, and identifying the molecular pathways, genetic subtypes, and mutations associated with CRC is crucial for precision medicine. However, traditional measurement techniques such as gene sequen...
Generalizable biomarker prediction from cancer pathology slides with self-supervised deep learning: A retrospective multi-centric study.
Cell reports. Medicine
Mar 22, 2023
Deep learning (DL) can predict microsatellite instability (MSI) from routine histopathology slides of colorectal cancer (CRC). However, it is unclear whether DL can also predict other biomarkers with high performance and whether DL predictions genera...
Deep Learning Prediction of Promoter Mutation Status in Thyroid Cancer Using Histologic Images.
Medicina (Kaunas, Lithuania)
Mar 9, 2023
objectives: Telomerase reverse transcriptase () promoter mutation, found in a subset of patients with thyroid cancer, is strongly associated with aggressive biologic behavior. Predicting promoter mutation is thus necessary for the prognostic strati...
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