Detecting pulmonary malignancy against benign nodules using noninvasive cell-free DNA fragmentomics assay.

Journal: ESMO open
PMID: 39088983

Abstract

BACKGROUND: Early screening using low-dose computed tomography (LDCT) can reduce mortality caused by non-small-cell lung cancer. However, ∼25% of the 'suspicious' pulmonary nodules identified by LDCT are later confirmed benign through resection surgery, adding to patients' discomfort and the burden on the healthcare system. In this study, we aim to develop a noninvasive liquid biopsy assay for distinguishing pulmonary malignancy from benign yet 'suspicious' lung nodules using cell-free DNA (cfDNA) fragmentomics profiling.

Authors

  • S Xu
  • J Luo
    Surgical Planning Lab (G.F., J.L., W.M.W.), Radiology Department, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
  • W Tang
    Department of Nephrology, Peking University Third Hospital, Beijing 100191, China.
  • H Bao
    School of Microelectronics and Control Engineering, Changzhou University, Changzhou 213164, China.
  • J Wang
    Joint Laboratory of Modern Agricultural Technology International Cooperation; Key Laboratory of Animal Production, Product Quality, and Security; College of Animal Science and Technology, Jilin Agricultural University, Changchun, China. moa4short@outlook.com.
  • S Chang
    Institut de Biomecanique Humaine Georges Charpak, Arts et Metiers Institute of Technology, Paris, France.
  • Z Zou
    The Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
  • X Fan
    Department of Pathology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, China.
  • Y Liu
    Google Health Palo Alto California USA.
  • C Jiang
    The Department of Thoracic Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
  • X Wu
    Center for Quantitative Genetics and Genomics, Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.

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