AIMC Topic: Liquid Biopsy
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Innovative technologies and their clinical prospects for early lung cancer screening.
Clinical and experimental medicine
Jun 18, 2025
BACKGROUND: Lung cancer remains the leading cause of cancer-related mortality worldwide, due to lacking effective early-stage screening approaches. Imaging, such as low-dose CT, poses radiation risk, and biopsies can induce some complications. Additi...
Liquid Biopsy: The Challenges of a Revolutionary Approach in Oncology.
International journal of molecular sciences
May 23, 2025
Liquid biopsy has gained attention in oncology as a non-invasive diagnostic tool, offering valuable insights into tumor biology through the analysis of circulating nucleic acid (cfDNA and cfRNA), circulating tumor cells (CTCs), extracellular vesicles...
Urinary biomarkers of kidney transplant rejection.
Current opinion in organ transplantation
Apr 2, 2025
PURPOSE OF REVIEW: Despite the introduction of many new immunosuppressive medications, allograft rejection remains a significant complication in transplantation. The use of "liquid biopsy" to evaluate allograft function and detect early rejection has...
Nano biosensor unlocks tumor derived immune signals for the early detection of ovarian cancer.
Biosensors & bioelectronics
Mar 10, 2025
Ovarian cancer is a critical health issue for women nowadays. Its impact is significant because of its high mortality rate (324,603 worldwide), late-stage diagnosis and poor survival rate. Lack of screening tests, vague symptoms, misdiagnosis, and ag...
Discovery of mutations predictive of survival benefit from immunotherapy in first-line NSCLC: A retrospective machine learning study of IMpower150 liquid biopsy data.
Computers in biology and medicine
Mar 4, 2025
Predictive biomarker identification in cancer treatment has traditionally relied on pre-defined analyses, limiting discoveries to expected biomarkers and potentially overlooking novel ones predictive of therapy response. In this work, we develop a no...
Liquid Biopsy
Clinical Trials, Phase III as Topic
Bevacizumab
Immunotherapy
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Non-Small-Cell Lung
Randomized Controlled Trials as Topic
Mutation
Paclitaxel
Male
Middle Aged
Lung Neoplasms
Female
Aged
Biomarkers, Tumor
Humans
Machine Learning
Retrospective Studies
Identification of 17 novel epigenetic biomarkers associated with anxiety disorders using differential methylation analysis followed by machine learning-based validation.
Clinical epigenetics
Feb 17, 2025
BACKGROUND: The changes in DNA methylation patterns may reflect both physical and mental well-being, the latter being a relatively unexplored avenue in terms of clinical utility for psychiatric disorders. In this study, our objective was to identify ...
Modernizing Neuro-Oncology: The Impact of Imaging, Liquid Biopsies, and AI on Diagnosis and Treatment.
International journal of molecular sciences
Jan 22, 2025
Advances in neuro-oncology have transformed the diagnosis and management of brain tumors, which are among the most challenging malignancies due to their high mortality rates and complex neurological effects. Despite advancements in surgery and chemor...
Artificial intelligence and machine learning in cell-free-DNA-based diagnostics.
Genome research
Jan 22, 2025
The discovery of circulating fetal and tumor cell-free DNA (cfDNA) molecules in plasma has opened up tremendous opportunities in noninvasive diagnostics such as the detection of fetal chromosomal aneuploidies and cancers and in posttransplantation mo...
Deep Learning-Enabled Rapid Metabolic Decoding of Small Extracellular Vesicles via Dual-Use Mass Spectroscopy Chip Array.
Analytical chemistry
Dec 23, 2024
The increasing focus of small extracellular vesicles (sEVs) in liquid biopsy has created a significant demand for streamlined improvements in sEV isolation methods, efficient collection of high-quality sEV data, and powerful rapid analysis of large d...
The Role of ctDNA in the Management of Non-Small-Cell Lung Cancer in the AI and NGS Era.
International journal of molecular sciences
Dec 20, 2024
Liquid biopsy (LB) involves the analysis of circulating tumour-derived DNA (ctDNA), providing a minimally invasive method for gathering both quantitative and qualitative information. Genomic analysis of ctDNA through next-generation sequencing (NGS) ...
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